Original Research
Elevated myocardial oxygen consumption during cutaneous cold stress in young adult overweight and obese Africans
Journal of Public Health in Africa | Vol 6, No 2 | a1006 |
DOI: https://doi.org/10.4081/jphia.2015.420
| © 2024 Toyib Olaniyan, Lawrence A. Olatunji
| This work is licensed under CC Attribution 4.0
Submitted: 25 November 2024 | Published: 17 August 2015
Submitted: 25 November 2024 | Published: 17 August 2015
About the author(s)
Toyib Olaniyan, Cardiovascular and Membrane Physiology Unit, Department of Physiology, University of Ilorin, Nigeria; and, Department of Public Health, University of Northampton, United Kingdom; and, Centre for Occupational and Environmental Health, University of Cape Town, South AfricaLawrence A. Olatunji, Cardiovascular and Membrane Physiology Unit, Department of Physiology, University of Ilorin, Nigeria
Full Text:
PDF (625KB)Abstract
Exaggerated sympathetic-mediated cardiovascular responses to stressful stimuli (such as cold exposure) has been linked to the development of hypertension and cardiovascular disease, which in turn has been demonstrated to predict the development of future hypertension. The aim of the present study was to test the hypothesis that enhanced change in myocardial oxygen consumption (MVO2) to cutaneous cold stress may be one potential mechanism that predisposes overweight/obese individuals in Africa to developing hypertension. The Rate-Pressure-Product (a non-invasive determinant of MVO2) was measured in normotensive young individuals aged between 18 and 25 years at baseline and during sympathetic activation elicited by cutaneous cold stimulation (CCS). Following CCS, there was a significant enhanced rate pressure product (RPP) change in overweight individuals (P=0.019). Furthermore, multivariate regression analysis showed that body mass index, but not body weight had a significant influence on RPP variation following CCS. Thus, it can be concluded that normotensive overweight or obese individuals have an exaggerated RPP response to the CCS. However, exposure to cold may augment sympathetic reactivity in overweight/obese individuals, which may contribute to increased risk of developing myocardial dysfunction, even in young normotensive individuals.
Keywords
cardiovascular health; obesity; young adults; sympathetic stimulation; myocardial
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