Original Article
Effects of fermented and non-fermented garlic as an anti-diabetic on blood glucose levels of wistar rat
Submitted: 10 April 2024 | Published: 25 May 2023
About the author(s)
Annis C. Adi, Nutrition Departement, Universitas Airlangga, Surabaya, IndonesiaYeni Susanti, Nutrition Departement, Universitas Airlangga, Surabaya, Indonesia
Heni Rachmawati, Institut Teknologi Bandung, Bandung, Indonesia
Emyr R. Ishaura, Nutrition Departement, Universitas Airlangga, Surabaya, Indonesia
Farapti Farapti, Nutrition Departement, Universitas Airlangga, Surabaya, Indonesia
Wizara Salisa, Rumah Inovasi Natura, Surabaya, Indonesia
Mohammad F. Rasyidi, Rumah Inovasi Natura, Surabaya, Indonesia
Nuthathai Sutthiwong, Thailand Institute of Scientific and Technological Research, Pathum Tani, Thailand
Full Text:
PDF (22MB)Abstract
Background: Garlic (Allium sativum Liin) is a root vegetable crop that is widely grown in different countries in the world. Garlic has chemical contents that are useful to health, like phytochemicals that are anti-diabetics, including flavonoids and saponins. Flavonoids and saponins have the function of deferring the absorption of carbohydrates so that glucose levels within the blood diminish.
Objective: This research aims to compare the effect of fermented garlic (FG) and non-fermented garlic (NFG) on insulin levels.
Materials and Methods: This study is an experimental laboratory in a completely randomized design. The study was completed in the Biochemistry Laboratory of Universitas Airlangga. The sample population in this study was 25 white male Wistar rats. The dosage of FG and NFG used in this study is 75mg/kg BW. Data analysis used the Tukey HSD test with a 95% confidence level. The average comparison test for each group was carried out using the significant (P<0.05) manova test.
Results: The results of this research indicate that the FG and NFG extract at a dose of 75 mg/kg BW can effectively decrease blood glucose levels, reduce malondialdehyde, and do not increase insulin levels.
Conclusions: All in all, garlic has antioxidant and antidiabetic properties and can decrease blood glucose levels in Wistar rats.
Keywords
Metrics
Total abstract views: 22Total article views: 2