A brief review on features of falciparum malaria during pregnancy

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Alexandre Manirakiza *
Eugène Serdouma
Richard Norbert Ngbalé
Sandrine Moussa
Samuel Gondjé
Rock Mbetid Degana
Gislain Géraud Banthas Bata
Jean Methode Moyen
Jean Delmont
Gérard Grésenguet
Abdoulaye Sepou
(*) Corresponding Author:
Alexandre Manirakiza | alexandre.manirakiza@pasteur-bangui.org

Abstract

Malaria in pregnancy is a serious public health problem in tropical areas. Frequently, the placenta is infected by accumulation of Plasmodium falciparum-infected erythrocytes in the intervillous space. Falciparum malaria acts during pregnancy by a range of mechanisms, and chronic or repeated infection and co-infections have insidious effects. The susceptibility of pregnant women to malaria is due to both immunological and humoral changes. Until a malaria vaccine becomes available, the deleterious effects of malaria in pregnancy can be avoided by protection against infection and prompt treatment with safe, effective antimalarial agents; however, concurrent infections such as with HIV and helminths during pregnancy are jeopardizing malaria control in sub-Saharan Africa.

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