Original Research – Special Collection: Vaccine Effectiveness in Africa

Enhancing health security in Africa: Collaboration between public health institutes and academia

Andrew Kambugu, Rodgers R. Ayebare, Francis Kakooza, Agnes Kiragga, Aster Tsegaye, Georgina Yeboah, Leah Mbabazi, Tonny Muwonge, Tamrat Shaweno, Nebiyu Dereje, Elizabeth Gonese, Mosoka P. Fallah, Tajudeen Raji, Ngashi Ngongo, Jean Kaseya
Journal of Public Health in Africa | Vol 16, No 1 | a780 | DOI: https://doi.org/10.4102/jphia.v16i1.780 | © 2025 Andrew Kambugu, Rodgers R. Ayebare, Francis Kakooza, Agnes Kiragga, Aster Tsegaye, Georgina Yeboah, Leah Mbabazi, Tonny Muwonge, Tamrat Shaweno, Nebiyu Dereje, Elizabeth Gonese, Mosoka P. Fallah, Tajudeen Raji, Ngashi Ngongo, Jean Kaseya | This work is licensed under CC Attribution 4.0
Submitted: 02 September 2024 | Published: 16 April 2025

About the author(s)

Andrew Kambugu, Infectious Diseases Institute, Makerere University, Kampala, Uganda
Rodgers R. Ayebare, Global Health Security Programme, Infectious Diseases Institute, Makerere University, Kampala, Uganda
Francis Kakooza, Global Health Security Programme, Infectious Diseases Institute, Makerere University, Kampala, Uganda
Agnes Kiragga, African Population and Health Research Centre, Nairobi, Kenya
Aster Tsegaye, Africa Forum for Research and Education in Health, Kumasi, Ghana; and, College of Health Sciences, University of Addis Ababa, Addis Ababa, Ethiopia
Georgina Yeboah, Africa Forum for Research and Education in Health, Kumasi, Ghana
Leah Mbabazi, Global Health Security Programme, Infectious Diseases Institute, Makerere University, Kampala, Uganda
Tonny Muwonge, Global Health Security Programme, Infectious Diseases Institute, Makerere University, Kampala, Uganda
Tamrat Shaweno, Africa Centers for Disease Control and Prevention, Addis Ababa, Ethiopia
Nebiyu Dereje, Africa Centers for Disease Control and Prevention, Addis Ababa, Ethiopia
Elizabeth Gonese, Africa Centers for Disease Control and Prevention, Addis Ababa, Ethiopia
Mosoka P. Fallah, Africa Centers for Disease Control and Prevention, Addis Ababa, Ethiopia
Tajudeen Raji, Africa Centers for Disease Control and Prevention, Addis Ababa, Ethiopia
Ngashi Ngongo, Africa Centers for Disease Control and Prevention, Addis Ababa, Ethiopia
Jean Kaseya, Africa Centers for Disease Control and Prevention, Addis Ababa, Ethiopia

Abstract

Background: The COVID-19 pandemic exposed significant challenges in Africa, including weak health systems, misinformation, limited vaccine access, and a lack of local data. Effective country-level leadership, coordination, and communication were crucial in addressing these multifaceted challenges.

Aim: The Program for Research on Vaccine Effectiveness (PROVE) was established to address these challenges by fostering international partnerships and advancing scientific knowledge generation toward implementing the Africa Centers for Disease Control and Prevention’s New Public Health Order.

Setting: The PROVE program is a collaborative initiative under the Saving Lives and Livelihoods initiative of Africa CDC and the Mastercard Foundation. It brings together a diverse network of researchers and policymakers from National Public Health Institutions and academia across Africa.

Methods: The programme employs a variety of qualitative and quantitative research methods, including surveys, interviews, focus groups, and analysis of existing data, along with capacity-building efforts.

Results: The PROVE program has achieved several significant results, including: developing evidence-based policy recommendations to strengthen DHIS2 and other data systems; strengthening the capacity of National Public Health Institutions; fostering collaboration among researchers, policymakers, and public health professionals; and promoting the use of local data for evidence-informed decision-making.

Conclusion: The PROVE programme’s collaborative approach is a valuable initiative with the potential to improve evidence generation and utilisation in Africa. By encouraging collaboration, knowledge generation and building capacity of local scientists in implementation science, the initiative helps address the challenges posed by the COVID-19 pandemic and builds resilience against future public health emergencies.

Contribution: This paper describes PROVE’s innovative approaches to generating new knowledge, developing practical approaches, and building capacity among African researchers in collaboration with policymakers.


Keywords

COVID-19; vaccines; collaboration; Africa health security; evidence-based public health; saving lives and livelihoods; research to action; health systems.

Sustainable Development Goal

Goal 3: Good health and well-being

Metrics

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