APOBEC3G expression and HIV-1 infection in Burkina Faso
DOI:
https://doi.org/10.4081/jphia.2018.907Keywords:
HIV-1, APOBEC3G mRNA, rs8177832, rs35228531, rs6001417, Burkina Faso.Abstract
APOBEC3G is a potent inhibitor of HIV-1 replication, and act by deaminating cytidines in uracil on the negative strand of the viral cDNA. In this case-control study, APOBEC3G expression in subjects’ naïve to HAART infected by HIV-1 and the effect of APOBEC3G polymorphism on its expression were evaluated. The results show that the HIV-1 infected carriers of the G minor alleles of the variant rs8177832 had a higher expression of APOBEC3G mRNA than the controls carriers of the G minor allele. APOBEC3G polymorphisms could play an important role in the modulation of the HIV-1 dissemination.
Download data is not yet available.
Published
21-12-2018
How to Cite
Compaore, T. R., Soubeiga, S. T., Ouattara, A. K., Tchelougou, D., Bisseye, C., Bakouan, D. R., Compaore, I., Dembele, A., Yonli, A. T., Obiri-Yeboah, D., Djigma, W. F., & Simpore, J. (2018). APOBEC3G expression and HIV-1 infection in Burkina Faso. Journal of Public Health in Africa, 9(3). https://doi.org/10.4081/jphia.2018.907
Issue
Section
Original Articles