APOBEC3G expression and HIV-1 infection in Burkina Faso

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Tegwinde Rebeca Compaore *
Serge Theophile Soubeiga
Abdoul Karim Ouattara
Damehan Tchelougou
Cyrille Bisseye
Didier Romuald Bakouan
Issaka Compaore
Augustine Dembele
Albert Theophane Yonli
Dorcas Obiri-Yeboah
Wendkuuni Florencia Djigma
Jacques Simpore
(*) Corresponding Author:
Tegwinde Rebeca Compaore | rebecca23fr@yahoo.fr

Abstract

APOBEC3G is a potent inhibitor of HIV-1 replication, and act by deaminating cytidines in uracil on the negative strand of the viral cDNA. In this case-control study, APOBEC3G expression in subjects’ naïve to HAART infected by HIV-1 and the effect of APOBEC3G polymorphism on its expression were evaluated. The results show that the HIV-1 infected carriers of the G minor alleles of the variant rs8177832 had a higher expression of APOBEC3G mRNA than the controls carriers of the G minor allele. APOBEC3G polymorphisms could play an important role in the modulation of the HIV-1 dissemination.


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