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Original Research
Prevalence of hepatitis C among HIV-1, HIV-2 and dually reactive patients: A multi-country cross-sectional survey in West Africa
Journal of Public Health in Africa | Vol 9, No 2 | a926 |
DOI: https://doi.org/10.4081/jphia.2018.871
| © 2024 Didier K. Ekouevi, Patrick A. Coffie, Boris K. Tchounga, Armel Poda, Antoine Jaquet, François Dabis, Serge P. Eholie
| This work is licensed under CC Attribution 4.0
Submitted: 18 November 2024 | Published: 01 October 2018
Submitted: 18 November 2024 | Published: 01 October 2018
About the author(s)
Didier K. Ekouevi, Université de Lomé, Département de Santé Publique, Lomé-Togo; and, ISPED, Université de Bordeaux and Centre INSERM U1219 - Bordeaux Population Health, Bordeaux, France; and, Programme PACCI, site de recherche ANRS, Côte d'IvoirePatrick A. Coffie, ISPED, Université de Bordeaux and Centre INSERM U1219 - Bordeaux Population Health, Bordeaux, France; Programme PACCI, site de recherche ANRS, Abidjan, Côte d’Ivoire; and, Département de Dermatologie et d’Infectiologie, UFR des Sciences Médicales, Université Félix Houphouët Boigny, Côte d'Ivoire
Boris K. Tchounga, ISPED, Université de Bordeaux and Centre INSERM U1219 - Bordeaux Population Health, Bordeaux, France; Programme PACCI, site de recherche ANRS, Abidjan, Côte d’Ivoire; and, Département de Dermatologie et d’Infectiologie, UFR des Sciences Médicales, Université Félix Houphouët Boigny, Côte d'Ivoire
Armel Poda, Université Polytechnique de Bobo, Institut Supérieur des Sciences de la Santé, Bobo-Dioulasso, Burkina Faso; and, Hôpital de Jour de Bobo, Service des Maladies Infectieuses (CHU Souro Sanou), Bobo-Dioulasso, Côte d'Ivoire
Antoine Jaquet, ISPED, Université de Bordeaux and Centre INSERM U1219 - Bordeaux Population Health, Bordeaux, France
François Dabis, ISPED, Université de Bordeaux and Centre INSERM U1219 - Bordeaux Population Health, Bordeaux, France; and, Programme PACCI, site de recherche ANRS, Abidjan, Côte d’Ivoire; and Département de Dermatologie et d’Infectiologie, UFR des Sciences Médicales, Université Félix Houphouët Boigny, Côte d'Ivoire
Serge P. Eholie, Programme PACCI, site de recherche ANRS, Côte d’Ivoire; and, Département de Dermatologie et d’Infectiologie, UFR des Sciences Médicales, Université Félix Houphouët Boigny, Côte d’Ivoire; and, Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Treichville, Côte d'Ivoire
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Little is known on the impact of HIV-2 infection on HCV viral replication. The aim of the study was to compare HCV prevalence and viral replication based on HIV types in West Africa. A cross-sectional survey was conducted within the IeDEA HIV-2 West Africa cohort from March to December 2012. All HIVinfected adult patients who attended participating HIV clinics during the study period were included. Blood samples were collected and re-tested for HIV type discrimination, HCV serology and viral load. A total of 767 patients were enrolled: 186 HIV-1, 431 HIV-2 and 150 HIV-1&2 dually reactive. At time of sampling, 531 (69.2%) were on ART and median CD4+ cell count was 472/mm3. Thirty (3.9%, 95% CI 2.7-5.5) patients were anti-HCV positive (4.3% in HIV-1, 4.0% in HIV-1&2 dually reactive and 3.7% in HIV-2; p=0.91). Detectable HCV RNA was identified in 21 (70.0%) patients (100% in HIV-1 and HIV- 1&2 dually reactive vs. 43.8% in HIV-2; p=0.003). Systematic screening should be promoted and performed in this population, since HCV is now potentially curable in sub- Saharan Africa.
Keywords
HIV-2; HCV; HBV; West Africa
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