Original Research

BRCA1 c.68_69delAG (exon2), c.181T>G (exon5), c.798_799delTT and 943ins10 (exon11) mutations in Burkina Faso

Abdou A. Zoure, Meriem Slaoui, Hierrhum A. Bambara, Alexis Y. Sawadogo, Tegwendé R. Compaoré, Nabonswindé L.M. Ouédraogo, Mohammed El Mzibri, Mohammed Attaleb, Si Simon Traoré, Jacques Simpore, Youssef Bakri
Journal of Public Health in Africa | Vol 9, No 1 | a929 | DOI: https://doi.org/10.4081/jphia.2018.663 | © 2024 Abdou A. Zoure, Meriem Slaoui, Hierrhum A. Bambara, Alexis Y. Sawadogo, Tegwendé R. Compaoré, Nabonswindé L.M. Ouédraogo, Mohammed El Mzibri, Mohammed Attaleb, Si Simon Traoré, Jacques Simpore, Youssef Bakri | This work is licensed under CC Attribution 4.0
Submitted: 19 November 2024 | Published: 21 May 2018

About the author(s)

Abdou A. Zoure, Pietro Annigoni Biomolecular Research Center (CERBA)/LABIOGENE, University of Ouaga1 Pr Joseph KI ZERBO, UFR/SVT, Burkina Faso; and, Laboratoiry of Biochemistry and Immunology, Faculty of Sciences, University of Mohammed V, Rabat, Morocco; and, Institute of Health Sciences Research (IRSS/CNRST)/Department of Biomedical and Public Health, Burkina Faso
Meriem Slaoui, Equipe of research ONCOGYMA, University of Mohamed V, Faculty of Medicine and Pharmacy of Rabat, Morocco
Hierrhum A. Bambara, Service of Oncology, University Hospital Yalgado Ouédraogo, Burkina Faso
Alexis Y. Sawadogo, Service of Gynecology, University Hospital Yalgado Ouédraogo, Burkina Faso
Tegwendé R. Compaoré, Pietro Annigoni Biomolecular Research Center (CERBA)/LABIOGENE, University of Ouagal Pr Joseph KI ZERBO, UFR/SVT, Burkina Faso
Nabonswindé L.M. Ouédraogo, Service of General Surgery and Digestive, University Hospital Yalgado Ouédraogo, Burkina Faso
Mohammed El Mzibri, Biology Unit and Medical Research, CNESTEN, Rabat, Morocco
Mohammed Attaleb, Biology Unit and Medical Research, CNESTEN, Rabat, Morocco
Si Simon Traoré, Service of General Surgery and Digestive, University Hospital Yalgado Ouédraogo, Burkina Faso
Jacques Simpore, Pietro Annigoni Biomolecular Research Center (CERBA)/LABIOGENE, University of Ouagal Pr Joseph KI ZERBO, UFR/SVT, Burkina Faso
Youssef Bakri, Laboratoiry of Biochemistry and Immunology, Faculty of Sciences, University of Mohammed V, Rabat, Morocco

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Abstract

The worldwide variation of BRCA mutations is well known. The c.68_69delAG, c.181T>G, c.798_799delTT mutations in BRCA1 were observed in Moroccan, Algerian and Tunisian Breast Cancer families and were described founder mutation in Northern Africa. The 943ins10 is also recognized a founder mutation in West Africa. To our knowledge no study has been published on BRCA1/2 germline mutations and hereditary breast cancer (HBC) in population of Burkina Faso. The aim of the present study (first in Burkina Faso) was to screen for these four mutations in 15 unrelated patients with HBC. Mutation analysis was performed by Sanger sequencing of coding exon2, Exon5 and exon11A sequences of the BRCA1 gene. Blood specimens of 15 patients from Burkina Faso, with HBC were collected at the University Hospital Yalgado OUEDRAOGO( CHU-YO) of Ouagadougou in Burkina Faso. c.68_69delAG (exon2), c.181T>G (exon5), c.798_799delTT and 943ins10 (exon11) mutations were not detected in any of the 15 women diagnosed with family breast cancer history. Genetic analysis in this study, we show that targeting relevant exons in BRCA1 genes did not allow detection of mutations in the population of Burkina Faso. Therefore, such an approach may be of interest to perfom a complete sequencing of BRCA1 and BRCA2 genes in families at a high risk of developing breast cancer in Burkina Faso.

Keywords

breast cancer; BRCA1; hereditary; Burkina Faso

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