Original Research

APOBEC3G expression and HIV-1 infection in Burkina Faso

Tegwinde R. Compaore, Serge T. Soubeiga, Abdoul K. Ouattara, Damehan Tchelougou, Cyrille Bisseye, Didier R. Bakouan, Issaka Compaore, Augustine Dembele, Albert T. Yonli, Dorcas Obiri-Yeboah, Wendkuuni F. Djigma, Jacques Simpore
Journal of Public Health in Africa | Vol 9, No 3 | a956 | DOI: https://doi.org/10.4081/jphia.2018.907 | © 2024 Tegwinde R. Compaore, Serge T. Soubeiga, Abdoul K. Ouattara, Damehan Tchelougou, Cyrille Bisseye, Didier R. Bakouan, Issaka Compaore, Augustine Dembele, Albert T. Yonli, Dorcas Obiri-Yeboah, Wendkuuni F. Djigma, Jacques Simpore | This work is licensed under CC Attribution 4.0
Submitted: 20 November 2024 | Published: 21 December 2018

About the author(s)

Tegwinde R. Compaore, Pietro Annigoni Biomolecular Research Centre (CERBA)/LABIOGENE, University of Ouagadougou, Burkina Faso
Serge T. Soubeiga, Pietro Annigoni Biomolecular Research Centre (CERBA)/LABIOGENE, University of Ouagadougou, Burkina Faso
Abdoul K. Ouattara, Pietro Annigoni Biomolecular Research Centre (CERBA)/LABIOGENE, University of Ouagadougou, Burkina Faso
Damehan Tchelougou, Pietro Annigoni Biomolecular Research Centre (CERBA)/LABIOGENE, University of Ouagadougou, Burkina Faso
Cyrille Bisseye, Pietro Annigoni Biomolecular Research Centre (CERBA)/LABIOGENE, University of Ouagadougou, Burkina Faso
Didier R. Bakouan, Permanent Secretary Against Aids and Sexually Transmitted Diseases, Ouagadougou, Burkina Faso
Issaka Compaore, Pietro Annigoni Biomolecular Research Centre (CERBA)/LABIOGENE, University of Ouagadougou, Burkina Faso
Augustine Dembele, Permanent Secretary Against Aids and Sexually Transmitted Diseases, Ouagadougou, Burkina Faso
Albert T. Yonli, Pietro Annigoni Biomolecular Research Centre (CERBA)/LABIOGENE, University of Ouagadougou, Burkina Faso
Dorcas Obiri-Yeboah, Microbiology Department, School of Medical Sciences, University of Cape Coast, Ghana
Wendkuuni F. Djigma, Pietro Annigoni Biomolecular Research Centre (CERBA)/LABIOGENE, University of Ouagadougou, Burkina Faso
Jacques Simpore, Pietro Annigoni Biomolecular Research Centre (CERBA)/LABIOGENE, University of Ouagadougou, Burkina Faso

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Abstract

APOBEC3G is a potent inhibitor of HIV-1 replication, and act by deaminating cytidines in uracil on the negative strand of the viral cDNA. In this case-control study, APOBEC3G expression in subjects’ naïve to HAART infected by HIV-1 and the effect of APOBEC3G polymorphism on its expression were evaluated. The results show that the HIV-1 infected carriers of the G minor alleles of the variant rs8177832 had a higher expression of APOBEC3G mRNA than the controls carriers of the G minor allele. APOBEC3G polymorphisms could play an important role in the modulation of the HIV-1 dissemination.

Keywords

HIV-1; APOBEC3G mRNA; rs8177832; rs35228531; rs6001417; Burkina Faso

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