Review Article

A brief review on features of falciparum malaria during pregnancy

Alexandre Manirakiza, Eugène Serdouma, Richard N. Ngbalé, Sandrine Moussa, Samuel Gondjé, Rock M. Degana, Gislain G.B. Bata, Jean M. Moyen, Jean Delmont, Gérard Grésenguet, Abdoulaye Sepou
Journal of Public Health in Africa | Vol 8, No 2 | a962 | DOI: https://doi.org/10.4081/jphia.2017.668 | © 2024 Alexandre Manirakiza, Eugène Serdouma, Richard N. Ngbalé, Sandrine Moussa, Samuel Gondjé, Rock M. Degana, Gislain G.B. Bata, Jean M. Moyen, Jean Delmont, Gérard Grésenguet, Abdoulaye Sepou | This work is licensed under CC Attribution 4.0
Submitted: 21 November 2024 | Published: 12 December 2017

About the author(s)

Alexandre Manirakiza, Pasteur Institute of Bangui, Bangui, Central African Republic
Eugène Serdouma, University of Bangui, Bangui, Central African Republic
Richard N. Ngbalé, University of Bangui, Bangui, Central African Republic
Sandrine Moussa, Pasteur Institute of Bangui, Bangui, Central African Republic
Samuel Gondjé, Ministry of Public Health, Population and AIDS Control, Bangui, Central African Republic
Rock M. Degana, Ministry of Public Health, Population and AIDS Control, Bangui, Central African Republic
Gislain G.B. Bata, Ministry of Public Health, Population and AIDS Control, Bangui, Central African Republic
Jean M. Moyen, Ministry of Public Health, Population and AIDS Control, Bangui, Central African Republic
Jean Delmont, Center for Training and Research in Tropical Medicine and Health, Faculty of Medicine North, Marseille, France
Gérard Grésenguet, University of Bangui, Bangui, Central African Republic
Abdoulaye Sepou, University of Bangui, Bangui, Central African Republic

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Abstract

Malaria in pregnancy is a serious public health problem in tropical areas. Frequently, the placenta is infected by accumulation of Plasmodium falciparum-infected erythrocytes in the intervillous space. Falciparum malaria acts during pregnancy by a range of mechanisms, and chronic or repeated infection and co-infections have insidious effects. The susceptibility of pregnant women to malaria is due to both immunological and humoral changes. Until a malaria vaccine becomes available, the deleterious effects of malaria in pregnancy can be avoided by protection against infection and prompt treatment with safe, effective antimalarial agents; however, concurrent infections such as with HIV and helminths during pregnancy are jeopardizing malaria control in sub-Saharan Africa.

Keywords

Malaria; Plasmodium falciparum; pregnancy

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