TY - JOUR AU - Ouedraogo, Serge Yannick AU - Tchelougou, Daméhan AU - Kologo, Jonas Koudougou AU - Sombie, Herman Karim AU - Zeye, Moutanou Modeste Judes AU - Compaore, Rebeca Tégwindé AU - Ouattara, Abdoul Karim AU - Sorgho, Abel Pegdwendé AU - Obiri-Yeboah, Dorcas Obiri-Yeboah AU - Soubeiga, Serge Théophile AU - Nagabila, Issoufou AU - Yonli, Albert Théophane AU - Djigma, Florencia Wendkuuni AU - Simpore, Jacques PY - 2020/10/29 Y2 - 2024/03/29 TI - No correlation between the variants of exostosin 2 gene and type 2 diabetes in Burkina Faso population JF - Journal of Public Health in Africa JA - J Public Health Afr VL - 11 IS - 1 SE - Original Articles DO - 10.4081/jphia.2020.1233 UR - https://publichealthinafrica.org/jphia/article/view/1233 SP - AB - <p>Recent genome-wide association studies and replication analyses have reported the association of variants of the exostosin- 2 gene (<em>EXT2</em>) and risk of type 2 diabetes (T2D) in some populations, but not in others. This study aimed to characterize the variants rs1113132, rs3740878 and rs11037909 of <em>EXT2</em> and to determine the existence of a possible correlation with T2D in Burkina Faso. It is a case-control study undertaken in Burkina Faso in the city of Ouagadougou at the Hospital of Saint Camille of Ouagadougou from December 2014 to June 2015. It relates to 121 type 2 diabetes cases and 134 controls. The genotyping of these polymorphisms was done by real-time PCR using the allelic exclusion method with TaqMan probes. The minor allele frequencies (MAFs) was almost identical in diabetic and control subjects for the all three Single Nucleotide Polymorphisms (SNPs) with no statistical significance, p&gt;0.05: rs1113132 (OR=0.89; p=0.82); rs11037909 (OR=0.89; p=0.74) and rs3740878 (OR=1.52; p=0.42). None of the three polymorphisms studied was associated with the risk of DT2. However, an association between the BMI, age and type 2 diabetes was noted. The variants of <em>EXT2</em> would not be associated to the risk of T2D in the African black population of Burkina Faso.</p> ER -