The effect of noni fruit (Morinda citrifolia L.) extract on interleukin 4 and interleukin 10 in Wistar rats, induced by pyrazinamide, ethambutol and levofloxacin


Published: 30 October 2019
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Authors

  • Thontowi Djauhari Nur Subchi Health Nutrition Department, Faculty of Public Health, Airlangga University, Surabaya; Anatomy Department, Medical Faculty of University of Muhammadiyah Malang, Indonesia.
  • Merryana Andriani Health Nutrition Department, Faculty of Public Health, Airlangga University, Surabaya, Indonesia.

Pyrazinamide, Ethambutol and Levofloxacin are part of the anti-tuberculosis SLD that have many side effects. This response causes an inflammatory reaction that affects pro-inflammatory cytokines interleukin 4 and interleukin 10. Morinda citrifolia L. produces anti-inflammatory activity that affects cytokines and provides protection against cell damage. A dose therapy was administered to wistar rats for two months, grouped in K- (negative control), K+ (positive control), MI (drug + Morinda citrifolia L. extract, dose of 100 mg/kg body weight), MII (drug + noni fruit extract, dose of 200 mg/kg body weight) and MIII (drug + noni fruit extract, dose of 400 mg/kg body weight). Results were examined using Rat IL-4 and IL-10 immunoassay Quantikine ELISA kits. The ANOVA (Analysis of Variance) test results showed that there was an overall IL-4 difference (sig<0.05); for IL-10 there was no great difference (sig>0.05); it was decrease trend was shown in MI and MII. However, by giving Morinda citrifolia L. extracts can significantly influence the IL-4 and IL-10, with a decreasing trend in MI and MII.


Subchi, T. D. N., & Andriani, M. (2019). The effect of noni fruit (Morinda citrifolia L.) extract on interleukin 4 and interleukin 10 in Wistar rats, induced by pyrazinamide, ethambutol and levofloxacin. Journal of Public Health in Africa, 10(s1). https://doi.org/10.4081/jphia.2019.1203

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