No correlation between the variants of exostosin 2 gene and type 2 diabetes in Burkina Faso population

Serge Yannick Ouedraogo; Daméhan Tchelougou; Jonas Koudougou Kologo; Herman Karim Sombie; Moutanou Modeste Judes Zeye; Rebeca Tégwindé Compaore; Abdoul Karim Ouattara; Abel Pegdwendé Sorgho; Dorcas Obiri-Yeboah Obiri-Yeboah; Serge Théophile Soubeiga; Issoufou Nagabila; Albert Théophane Yonli; Florencia Wendkuuni Djigma; Jacques Simpore

doi:10.4081/jphia.2020.1233

Authors

Serge Yannick Ouedraogo Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou, Burkina Faso. https://orcid.org/0000-0002-4998-8596
Daméhan Tchelougou Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou, Burkina Faso.
Jonas Koudougou Kologo Saint Camille Hospital (HOSCO), Ouagadougou, Burkina Faso.
Herman Karim Sombie Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou, Burkina Faso. https://orcid.org/0000-0001-6996-8990
Moutanou Modeste Judes Zeye Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou, Burkina Faso. https://orcid.org/0000-0002-3407-9576
Rebeca Tégwindé Compaore Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou; Biomolecular Research Center Pietro Annigoni (CERBA), Ouagadougou, Burkina Faso.
Abdoul Karim Ouattara Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou, Burkina Faso. https://orcid.org/0000-0002-9767-0646
Abel Pegdwendé Sorgho Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou, Burkina Faso.
Dorcas Obiri-Yeboah Obiri-Yeboah Department of Microbiology and Immunology, School of Medical Sciences, University of Cape Coast, Ghana. https://orcid.org/0000-0003-4562-9294
Serge Théophile Soubeiga Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou, Burkina Faso. https://orcid.org/0000-0002-9741-2428
Issoufou Nagabila Saint Camille Hospital (HOSCO), Ouagadougou, Burkina Faso.
Albert Théophane Yonli Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou; Biomolecular Research Center Pietro Annigoni (CERBA), Ouagadougou, Burkina Faso.
Florencia Wendkuuni Djigma
florencia.djigma@gmail.com
Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou; Biomolecular Research Center Pietro Annigoni (CERBA), Ouagadougou;, Burkina Faso. https://orcid.org/0000-0002-6895-6725
Jacques Simpore Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou; Saint Camille Hospital (HOSCO), Ouagadougou; Biomolecular Research Center Pietro Annigoni (CERBA), Ouagadougou, Burkina Faso. https://orcid.org/0000-0002-0415-9161

Recent genome-wide association studies and replication analyses have reported the association of variants of the exostosin- 2 gene (EXT2) and risk of type 2 diabetes (T2D) in some populations, but not in others. This study aimed to characterize the variants rs1113132, rs3740878 and rs11037909 of EXT2 and to determine the existence of a possible correlation with T2D in Burkina Faso. It is a case-control study undertaken in Burkina Faso in the city of Ouagadougou at the Hospital of Saint Camille of Ouagadougou from December 2014 to June 2015. It relates to 121 type 2 diabetes cases and 134 controls. The genotyping of these polymorphisms was done by real-time PCR using the allelic exclusion method with TaqMan probes. The minor allele frequencies (MAFs) was almost identical in diabetic and control subjects for the all three Single Nucleotide Polymorphisms (SNPs) with no statistical significance, p>0.05: rs1113132 (OR=0.89; p=0.82); rs11037909 (OR=0.89; p=0.74) and rs3740878 (OR=1.52; p=0.42). None of the three polymorphisms studied was associated with the risk of DT2. However, an association between the BMI, age and type 2 diabetes was noted. The variants of EXT2 would not be associated to the risk of T2D in the African black population of Burkina Faso.

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Ouedraogo, S. Y., Tchelougou, D., Kologo, J. K., Sombie, H. K., Zeye, M. M. J., Compaore, R. T., Ouattara, A. K., Sorgho, A. P., Obiri-Yeboah, D. O.-Y., Soubeiga, S. T., Nagabila, I., Yonli, A. T., Djigma, F. W., & Simpore, J. (2020). No correlation between the variants of exostosin 2 gene and type 2 diabetes in Burkina Faso population. Journal of Public Health in Africa, 11(1). https://doi.org/10.4081/jphia.2020.1233