No correlation between the variants of exostosin 2 gene and type 2 diabetes in Burkina Faso population

Authors

  • Serge Yannick Ouedraogo Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou https://orcid.org/0000-0002-4998-8596
  • Daméhan Tchelougou Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou
  • Jonas Koudougou Kologo Saint Camille Hospital (HOSCO), Ouagadougou
  • Herman Karim Sombie Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou https://orcid.org/0000-0001-6996-8990
  • Moutanou Modeste Judes Zeye Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou https://orcid.org/0000-0002-3407-9576
  • Rebeca Tégwindé Compaore Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou; Biomolecular Research Center Pietro Annigoni (CERBA), Ouagadougou
  • Abdoul Karim Ouattara Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou https://orcid.org/0000-0002-9767-0646
  • Abel Pegdwendé Sorgho Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou
  • Dorcas Obiri-Yeboah Obiri-Yeboah Department of Microbiology and Immunology, School of Medical Sciences, University of Cape Coast https://orcid.org/0000-0003-4562-9294
  • Serge Théophile Soubeiga Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou https://orcid.org/0000-0002-9741-2428
  • Issoufou Nagabila Saint Camille Hospital (HOSCO), Ouagadougou
  • Albert Théophane Yonli Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou; Biomolecular Research Center Pietro Annigoni (CERBA), Ouagadougou
  • Florencia Wendkuuni Djigma Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou; Biomolecular Research Center Pietro Annigoni (CERBA), Ouagadougou; https://orcid.org/0000-0002-6895-6725
  • Jacques Simpore Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou; Saint Camille Hospital (HOSCO), Ouagadougou; Biomolecular Research Center Pietro Annigoni (CERBA), Ouagadougou https://orcid.org/0000-0002-0415-9161

DOI:

https://doi.org/10.4081/jphia.2020.1233

Keywords:

Type 2 Diabetes, Exostosin-2, association, SNPs, Burkina Faso

Abstract

Recent genome-wide association studies and replication analyses have reported the association of variants of the exostosin- 2 gene (EXT2) and risk of type 2 diabetes (T2D) in some populations, but not in others. This study aimed to characterize the variants rs1113132, rs3740878 and rs11037909 of EXT2 and to determine the existence of a possible correlation with T2D in Burkina Faso. It is a case-control study undertaken in Burkina Faso in the city of Ouagadougou at the Hospital of Saint Camille of Ouagadougou from December 2014 to June 2015. It relates to 121 type 2 diabetes cases and 134 controls. The genotyping of these polymorphisms was done by real-time PCR using the allelic exclusion method with TaqMan probes. The minor allele frequencies (MAFs) was almost identical in diabetic and control subjects for the all three Single Nucleotide Polymorphisms (SNPs) with no statistical significance, p>0.05: rs1113132 (OR=0.89; p=0.82); rs11037909 (OR=0.89; p=0.74) and rs3740878 (OR=1.52; p=0.42). None of the three polymorphisms studied was associated with the risk of DT2. However, an association between the BMI, age and type 2 diabetes was noted. The variants of EXT2 would not be associated to the risk of T2D in the African black population of Burkina Faso.

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Published

29-10-2020

How to Cite

Ouedraogo, S. Y., Tchelougou, D., Kologo, J. K., Sombie, H. K., Zeye, M. M. J., Compaore, R. T., Ouattara, A. K., Sorgho, A. P., Obiri-Yeboah, D. O.-Y., Soubeiga, S. T., Nagabila, I., Yonli, A. T., Djigma, F. W., & Simpore, J. (2020). No correlation between the variants of exostosin 2 gene and type 2 diabetes in Burkina Faso population. Journal of Public Health in Africa, 11(1). https://doi.org/10.4081/jphia.2020.1233

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Original Articles