Antibiotic consumption history of patients in a referred laboratory in Yaounde
Accepted: 3 July 2022
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Background. Regulation of antibiotic prescription and consumption remains a major public health burden in low- and middle- income countries.
Objective. This study aimed to describe the antibiotic consumption of patients who had a positive antibiotic culture in a reference laboratory.
Methods. A retrospective descriptive study was conducted among 113 participants with positive antibiograms with a documented history of antibiotics intake at the Yaoundé University Teaching Hospital in Cameroon between January 2016 and June 2021. Data were stored and analyzed using the Census and Survey Processing System version 7.3 and Statistical Package for Social Science version 25.0. Descriptive statistics were used to estimate the indicators.
Results. Of the 113 patients enrolled, 105 had a history of drug use; 56 participants (53.3%) had taken at least 2 antibiotics prior to sampling. Cephalosporins were the most consumed antibiotics (41%), followed by nitroimidazols (28.6%) and penicillins (28.6%). According to the World Health Organization classification, 55 (52.4%) took major priority antibiotics.
Conclusion. We are on the alert and there is an urgent need to raise awareness among clinicians and patients alike by providing them with good clinical practice guidelines.
Muloi D, Fèvre EM, Bettridge J, et al. A cross-sectional survey of practices and knowledge among antibiotic retailers in Nairobi, Kenya. J Glob Health 2019;9:020412.
Wojkowska-Mach J, Godman B, Glassman A, et al. Antibiotic consumption and antimicrobial resistance in Poland; findings and implications. Antimicrob Resist Infect Control 2018;7:136.
Limmathurotsakul D, Sandoe JAT, Barret DC, et al. Antibiotic footprint as a communication tool to aid reduction of antibiotic consumption. J Antimicrob Chemother 2019;74:3406-8.
Barberi G, De Cola MC, Dell’Utri DC, et al. Antimicrobial consumption and antimicrobial resistance: a snapshot of an Italian neuromuscular rehabilitation center. New Microbiol 2017;40:119-29.
Mouiche MMM, Moffo F, Betsama JDB, et al. Challenges of antimicrobial consumption surveillance in food-producing animals in sub-saharan african countries: patterns of antimicrobials imported in Cameroon from 2014 to 2019. J Glob Antimicrob Resist 2020;22:771-8.
Masich AM, Vega AD, Callahan P, et al. Antimicrobial usage at a large teaching hospital in Lusaka, Zambia. PloS One 2020;15:e0228555.
Bessong PO, Guerrant RL. Improving our understanding of antibiotic resistance: the relevance of surveillance at the population level. S Afr Med J 2017;107:11827.
Duval RE, Grare M, Demoré B. Fight against antimicrobial resistance: we always need new antibacterials but for right bacteria. Molecules 2019;24:3152.
Mbwasi R, Mapunjo S, Wittenauer R, et al. National consumption of antimicrobials in Tanzania: 2017-2019. Front Pharmacol 2020;11:585553.
Cox JA, Vlieghe E, Mendelson M, et al. Antibiotic stewardship in low- and middle-income countries: the same but different? Clin Microbiol Infect 2017;23:812-8.
WHO. Global antimicrobial resistance surveillance system (GLASS). Available from: https://www.who.int/initiatives/glass. Accessed: 11 February 2021.
Howard P, Pulcini C, Levy Hara G, et al. An international cross-sectional survey of antimicrobial stewardship programmes in hospitals. J Antimicrob Chemother 2015;70:1245-55.
Grundmann H. Towards a global antibiotic resistance surveillance system: a primer for a roadmap. Ups J Med Sci 2014;119:87-95.
OMS. Liste OMS des antibiotiques d’importance critique pour la médécine humaine, 2019. Available from: https://apps.who.int/iris/bitstream/handle/10665/325035/WHO-NMH-FOS-FZD-19.1-fre.pdf?ua=1.
Société Française de Microbiologie. Determination de la sensibilité aux antibiotiques. In : CA-SFM / EUCAST : Société Française de Microbiologie Ed ; 2022: p.06-25.
Barchitta M, Quattrocchi A, Maugeri A, et al. Antibiotic consumption and resistance during a 3-year period in Sicily, Southern Italy. Int J Environ Res Public Health 2019;16:2253.
Ganguly NK, Arora NK, Chandy SJ, et al. Rationalizing antibiotic use to limit antibiotic resistance in India. Indian J Med Res 2011;134:281-94.
Okoth C, Opanga S, Okalebo F, et al. Point prevalence survey of antibiotic use and resistance at a referral hospital in Kenya: findings and implications. Hosp Pract 2018;46:128-36.
Versporten A, Zarb P, Caniaux I, et al. Antimicrobial consumption and resistance in adult hospital inpatients in 53 countries: results of an internet-based global point prevalence survey. Lancet Glob Health 2018;6:e619-29.
Ngu R, Feteh VF, Kika BFE, et al. Prevalence and determinants of antibiotic self-medication among adult patients with respiratory tract infections in the Mboppi Baptist Hospital, Douala, Cameroon: a cross-sectional study. Diseases 2018;6:49.
Finlayson H, Versporten A, Whitelaw A, et al. The global point prevalence survey of antimicrobial consumption and resistance; (Global-PPS): results of antimicrobial prescribing in a South African tertiary hospital. Available from: https://www.global-pps.com/wp-content/uploads/2016/04/ECCMID-2016_South-Africa.pdf.
Umeokonkwo CD, Madubueze UC, Onah CK, et al. Point prevalence survey of antimicrobial prescription in a tertiary hospital in South East Nigeria: a call for improved antibiotic stewardship. J Glob Antimicrob Resist 2019;17:291-5.
van de Maat J, van de Voort E, Mintegi S, et al. Antibiotic prescription for febrile children in European emergency departments: a cross-sectional, observational study. Lancet Infect Dis 2019;19:382-91.
Zhang JS, Liu G, Zhang WS, et al. Antibiotic usage in chinese children: a point prevalence survey. World J Pediatr 2018;14:335-43.
Amaha ND, Weldemariam DG, Berhe YH. Antibiotic consumption study in two hospitals in Asmara from 2014 to 2018 using WHO’s defined daily dose (DDD) methodology. PLoS One 2020;15:e0233275.
Copyright (c) 2023 the Authors
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.