Antibiotic resistance of bacteria responsible for postoperative wound infections seen in the laboratory of the University Hospital of Befelatanana

Authors

  • Zafindrasoa Domoina Rakotovao-Ravahatra Laboratory of the University Hospital of Joseph Raseta Befelatanana, Medical Biology Department, Faculty of Medicine, University of Antananarivo https://orcid.org/0000-0002-2449-9526
  • Fidiniaina Mamy Randriatsarafara National Institute of Public and Community Health, Department of Public Health, Faculty of Medicine, University of Antananarivo
  • Joely Nirina Rakotovao-Ravahatra Doctoral School ‘Engineering of Industrial, Agricultural and Food Processes and Systems’, Graduate School of Agronomic Sciences, University of Antananarivo
  • Andriamiadana Luc Rakotovao Laboratory of the University Hospital of Joseph Raseta Befelatanana, Medical Biology Department, Faculty of Medicine, University of Antananarivo https://orcid.org/0000-0003-4511-4717

DOI:

https://doi.org/10.4081/jphia.2023.2307

Keywords:

Pus, antibiotic resistance, imipenem, amikacin

Abstract

The management of postoperative wound infections is a major problem in hospitals due to the frequent ineffectiveness of antibiotic treatment. The objectives of this study are to identify the bacteria responsible for postoperative wound infections and to describe these antibiotic resistances in order to improve the management of these infections. It is a prospective study of 52 bacteriological results of postoperative wounds for a period of six months from January 2021 to June 2021 in the laboratory of the University Hospital of Befelatanana. This study showed 26 (50%) isolates of staphylococci, 17 (32.7%) isolates of enterobacteria, 6 (11.5%) isolates of streptococci and 3 (5.8%) isolates of nonfermenting gram‑negatif bacilli. Antibiotic resistance, varies from 0% (vancomycin) to 92.3% (penicillin G) for staphylococci isolates, 0% (imipenem, amikacin) to 94.1% (amoxicillin) for enterobacteria isolates, 0% (vancomycin) to 50% (penicillin G) for streptococci isolates and 33% (imipenem, amikacin) to 100% (cotrimoxazole) for the isolates of nonfermenting gram‑negatif bacilli. The knowledge of antibiotic resistance of bacteria responsible for postoperative wound infections allows better patient management.

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References

Barie PS and Wilson SE: Impact of evolving epidemiology on treatments for complicated skin and skin structure infections: the surgical perspective. J Am Coll Surg 220: 105‑106.6e, 2015.

Cheadle WG: Risk factors for surgical site infection. Surg Infect (Larchmt) 7 (Suppl 1): S7‑S11, 2006.

Azoury S, Farrow N, Hu Q, Soares K, Hicks C, Azar F, Rodriguez‑Unda N, Poruk K, Cornell P, Burce K, et al: Postoperative abdominal wound infection‑epidemiology, risk factors, identification, and management. Chronic Wound Care Manag Res 2: 137‑138, 2015.

Diener MK, Knebel P, Kieser M, Schüler P, Schiergens TS, Atanassov V, Neudecker J, Stein E, Thielemann H, Kunz R, et al: Effectiveness of triclosan‑coated PDS Plus versus uncoated PDS II sutures for prevention of surgical site infection after abdominal wall closure: the randomised controlled PROUD trial. Lancet 384: 142‑152, 2014.

Pinkney TD, Calvert M, Bartlett DC, Gheorghe A, Redman V, Dowswell G, Hawkins W, Mak T, Youssef H, Richardson C, et al: Impact of wound edge protection devices on surgical site infection after laparotomy: multicentre randomised controlled trial (ROSSINI Trial). BMJ 347: f4305, 2013.

Mihaljevic AL, Schirren R, Özer M, Ottl S, Grün S, Michalski CW, Erkan M, Jäger C, Reiser‑Erkan C, Kehl V, et al: Multicenter double‑blinded randomized controlled trial of standard abdominal wound edge protection with surgical dressings versus coverage with a sterile circular polyethylene drape for prevention of surgical site infections: a CHIR‑Net trial (BaFO; NCT01181206). Ann Surg 260: 730‑737, 2014.

Société Française de Microbiologie. Tables of critical concentrations for the interpretation of MICs and critical diameters of inhibition zones. In: CASFM/EUCAST: Société Française de Microbiologie Ed; 2019: 38‑94.

Kalra L, Camacho F, Whitener CJ, Du P, Miller M, Zalonis C and Julian KG: Risk of methicillin‑resistant Staphylococcus aureus surgical site infection in patients with nasal MRSA colonization. Am J Infect Control 41: 1253‑1257, 2013.

Stevens DL, Bisno AL, Chambers HF, Dellinger EP, Goldstein EJ, Gorbach SL, Hirschmann JV, Kaplan SL, Montoya JG and Wade JC; Infectious Diseases Society of America: Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America. Clin Infect Dis 59:e10‑e52, 2014.

Randriatsarafara FM, Ralamboson J, Rakotoarivelo R, Raherinandrasana A and Andrianasolo R: Antibiotic consumption at Antananarivo University Hospital: prevalence and strategic challenges. Santé Publique 27: 249‑255, 2015 (In Article in French).

Ebongue CO, Tsiazok MD, Nda Mefo'o JP, Ngaba GP, Beyiha G and Adiogo D: Evolution of antibiotic resistance of Enterobacteriaceae isolated at the Douala General Hospital from 2005 to 2012. Pan Afr Med J 20: 227, 2015 (In Article in French).

Karlik JB, Duron V, Mermel LA and Mazzaglia P: Severe group a streptococcus surgical site infection after thyroid lobectomy. Surg Infect (Larchmt) 14: 216‑220, 2013.

Bisno AL, Gerber MA, Gwaltney JM, Kaplan EL and Schwartz RH; Infectious Diseases Society of America: Practice guidelines for the diagnosis and management of group a streptococcal pharyngitis. Clin Infect Dis 35: 113‑125, 2002.

Bogomolova NS, Bol'shakov LV, Kuznetsova SM and Oreshkina TD: Nonfermentative gram‑negative bacteria: isolation rates and antibiotic sensitivity. Anesteziol Reanimatol 3: 12‑18, 2010 (In Article in Russian).

McGowan JE: Resistance in nonfermenting gram‑negative bacteria: multidrug resistance to the maximum. Am J Med 119 (6 Suppl 1): S29‑S36, 2006.

Goudarzi H, Douraghi M, Ghalavand Z and Goudarzi M: Assessment of antibiotic resistance pattern in Acinetobacter baumannii carrying bla oxA type genes isolated from hospitalized patients. Novel Biomed 1: 54‑61, 2013.

Baruah FK, Hussain AN, Kausalya, Grover RK: Antibiotic resistance profile of non‑fermenting Gram‑negative bacilli isolated from the blood cultures of cancer patients. J Glob Infec Dis 7: 46‑47, 2015.

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Published

30-08-2023

How to Cite

Rakotovao-Ravahatra, Z. D., Randriatsarafara, F. M., Rakotovao-Ravahatra, J. N., & Rakotovao, A. L. (2023). Antibiotic resistance of bacteria responsible for postoperative wound infections seen in the laboratory of the University Hospital of Befelatanana. Journal of Public Health in Africa, 14(9). https://doi.org/10.4081/jphia.2023.2307

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Original Articles