Assessment of the appropriateness of antibiotic prescriptions in Lesotho public hospitals: a novel methodology based on principles of antibiotic prescribing


Submitted: 28 June 2013
Accepted: 4 February 2014
Published: 13 May 2014
Abstract Views: 1624
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Authors

  • Matthias Adorka School of Pharmacy, University of Namibia, Windhoek, Namibia.
  • Honoré Kabwebwe Mitonga Department of Community Medicine, University of Namibia, Windhoek, Namibia.
  • Martie Lubbe Medicine Usage in South Africa, School of Pharmacy, North-West University, Potchefstroom, South Africa.
  • Jan Serfontein Medicine Usage in South Africa, School of Pharmacy, North-West University, Potchefstroom, South Africa.
  • Kirk Allen Medical and Pharmaceutical Biotechnology Unit, Research Center in Technology and Design Assistance of Jalisco State (CIATEJ), Guadalajara, Mexico.
The study primarily aimed at assessing the appropriateness of antibiotic prescriptions in a section of public health institutions in Lesotho using an assessment tool formulated from principles of antibiotic prescribing. Relevant data on procedures of infection diagnosis and prescribed antibiotics were collected from both inpatient and outpatient case reports for a onemonth period in five public hospitals in Lesotho. These were analyzed for the appropriateness of the prescribed antibiotics. Prescription appropriateness assessment was based on conformities of prescribed antibiotics to criteria developed from pertinent principles of antibiotic prescribing. Assessed prescriptions, 307 inpatient and 865 outpatient prescriptions in total, were classified into categories of appropriateness based on extents to which they satisfied conditions defined by combinations of criteria in the assessment tool. Antibiotic prescriptions from inpatient and outpatient departments of study site hospitals were categorized into groups of different degrees of appropriateness. A total of 32.2% inpatient prescriptions and 78.4% outpatient prescriptions assessed were appropriately written for the empiric treatment of infections for which bacterial pathogens were considered absolute or possible etiologies. The use of prescription assessment tools based on principles of antibiotic prescribing is a feasible option of assessing the appropriateness of antibiotic prescriptions, particularly in low-income countries where expert panels cannot be formed.

Supporting Agencies

This project and the preparations of all reports thereof were funded partly from resources of the first author and a research grant from the National University of Lesotho.

Adorka, M., Kabwebwe Mitonga, H., Lubbe, M., Serfontein, J., & Allen, K. (2014). Assessment of the appropriateness of antibiotic prescriptions in Lesotho public hospitals: a novel methodology based on principles of antibiotic prescribing. Journal of Public Health in Africa, 5(1). https://doi.org/10.4081/jphia.2014.354

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