A brief review on features of falciparum malaria during pregnancy

Alexandre Manirakiza; Eugène Serdouma; Richard Norbert Ngbalé; Sandrine Moussa; Samuel Gondjé; Rock Mbetid Degana; Gislain Géraud Banthas Bata; Jean Methode Moyen; Jean Delmont; Gérard Grésenguet; Abdoulaye Sepou

doi:10.4081/jphia.2017.668

A brief review on features of falciparum malaria during pregnancy

https://doi.org/10.4081/jphia.2017.668

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Vol. 8 No. 2 (2017)

Submitted: 24 March 2017
Accepted: 17 August 2017

Published: 31 December 2017

Malaria, Plasmodium falciparum, pregnancy

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Authors

Alexandre Manirakiza
alexandre.manirakiza@pasteur-bangui.org
Pasteur Institute of Bangui, Bangui, Central African Republic. http://orcid.org/0000-0002-1873-8527
Eugène Serdouma University of Bangui, Bangui, Central African Republic.
Richard Norbert Ngbalé University of Bangui, Bangui, Central African Republic.
Sandrine Moussa Pasteur Institute of Bangui, Bangui, Central African Republic.
Samuel Gondjé Ministry of Public Health, Population and AIDS Control, Bangui, Central African Republic.
Rock Mbetid Degana Ministry of Public Health, Population and AIDS Control, Bangui, Central African Republic.
Gislain Géraud Banthas Bata Ministry of Public Health, Population and AIDS Control, Bangui, Central African Republic.
Jean Methode Moyen Ministry of Public Health, Population and AIDS Control, Bangui, Central African Republic.
Jean Delmont Center for Training and Research in Tropical Medicine and Health, Faculty of Medicine North, Marseille, France.
Gérard Grésenguet University of Bangui, Bangui, Central African Republic.
Abdoulaye Sepou University of Bangui, Bangui, Central African Republic.

Malaria in pregnancy is a serious public health problem in tropical areas. Frequently, the placenta is infected by accumulation of Plasmodium falciparum-infected erythrocytes in the intervillous space. Falciparum malaria acts during pregnancy by a range of mechanisms, and chronic or repeated infection and co-infections have insidious effects. The susceptibility of pregnant women to malaria is due to both immunological and humoral changes. Until a malaria vaccine becomes available, the deleterious effects of malaria in pregnancy can be avoided by protection against infection and prompt treatment with safe, effective antimalarial agents; however, concurrent infections such as with HIV and helminths during pregnancy are jeopardizing malaria control in sub-Saharan Africa.

Supporting Agencies

Institut Pasteur of Bangui

Manirakiza, A., Serdouma, E., Ngbalé, R. N., Moussa, S., Gondjé, S., Mbetid Degana, R., Banthas Bata, G. G., Moyen, J. M., Delmont, J., Grésenguet, G., & Sepou, A. (2017). A brief review on features of falciparum malaria during pregnancy. Journal of Public Health in Africa, 8(2). https://doi.org/10.4081/jphia.2017.668