Prevalence of hepatitis C among HIV-1, HIV-2 and dually reactive patients: A multi-country cross-sectional survey in West Africa


Submitted: 12 February 2018
Accepted: 5 July 2018
Published: 10 October 2018
Abstract Views: 1098
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Authors

  • Didier K. Ekouevi Université de Lomé, Département de Santé Publique, Lomé-Togo, ISPED, Université de Bordeaux and Centre INSERM U1219 - Bordeaux Population Health, Bordeaux, France; Programme PACCI, site de recherche ANRS, Abidjan, Côte d'Ivoire.
  • Patrick A. Coffie ISPED, Université de Bordeaux and Centre INSERM U1219 - Bordeaux Population Health, Bordeaux, France; Programme PACCI, site de recherche ANRS, Abidjan, Côte d’Ivoire; Département de Dermatologie et d’Infectiologie, UFR des Sciences Médicales, Université Félix Houphouët Boigny, Abidjan, Côte d'Ivoire.
  • Boris K. Tchounga ISPED, Université de Bordeaux and Centre INSERM U1219 - Bordeaux Population Health, Bordeaux, France; Programme PACCI, site de recherche ANRS, Abidjan, Côte d’Ivoire; Département de Dermatologie et d’Infectiologie, UFR des Sciences Médicales, Université Félix Houphouët Boigny, Abidjan, Côte d'Ivoire.
  • Armel Poda Université Polytechnique de Bobo, Institut Supérieur des Sciences de la Santé, Bobo-Dioulasso, Burkina Faso; Hôpital de Jour de Bobo, Service des Maladies Infectieuses (CHU Souro Sanou), Bobo-Dioulasso, Burkina Faso.
  • Antoine Jaquet ISPED, Université de Bordeaux and Centre INSERM U1219 - Bordeaux Population Health, Bordeaux, France.
  • François Dabis ISPED, Université de Bordeaux and Centre INSERM U1219 - Bordeaux Population Health, Bordeaux, France; Programme PACCI, site de recherche ANRS, Abidjan, Côte d’Ivoire; Département de Dermatologie et d’Infectiologie, UFR des Sciences Médicales, Université Félix Houphouët Boigny, Abidjan, Côte d'Ivoire.
  • Serge P. Eholie Programme PACCI, site de recherche ANRS, Abidjan; Département de Dermatologie et d’Infectiologie, UFR des Sciences Médicales, Université Félix Houphouët Boigny, Abidjan; Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Treichville, Abidjan, Côte d'Ivoire.

Little is known on the impact of HIV-2 infection on HCV viral replication. The aim of the study was to compare HCV prevalence and viral replication based on HIV types in West Africa. A cross-sectional survey was conducted within the IeDEA HIV-2 West Africa cohort from March to December 2012. All HIVinfected adult patients who attended participating HIV clinics during the study period were included. Blood samples were collected and re-tested for HIV type discrimination, HCV serology and viral load. A total of 767 patients were enrolled: 186 HIV-1, 431 HIV-2 and 150 HIV-1&2 dually reactive. At time of sampling, 531 (69.2%) were on ART and median CD4+ cell count was 472/mm3. Thirty (3.9%, 95% CI 2.7-5.5) patients were anti-HCV positive (4.3% in HIV-1, 4.0% in HIV-1&2 dually reactive and 3.7% in HIV-2; p=0.91). Detectable HCV RNA was identified in 21 (70.0%) patients (100% in HIV-1 and HIV- 1&2 dually reactive vs. 43.8% in HIV-2; p=0.003). Systematic screening should be promoted and performed in this population, since HCV is now potentially curable in sub- Saharan Africa.


Supporting Agencies

National Cancer Institute (NCI), the Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), and the National Institute of Allergy and Infectious Diseases (NIAID) of the US National Institutes of Health (NIH)

Ekouevi, D. K., Coffie, P. A., Tchounga, B. K., Poda, A., Jaquet, A., Dabis, F., & Eholie, S. P. (2018). Prevalence of hepatitis C among HIV-1, HIV-2 and dually reactive patients: A multi-country cross-sectional survey in West Africa. Journal of Public Health in Africa, 9(2). https://doi.org/10.4081/jphia.2018.871

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