APOBEC3G expression and HIV-1 infection in Burkina Faso


https://doi.org/10.4081/jphia.2018.907
Vol. 9 No. 3 (2018)
Submitted: 7 May 2018
Accepted: 14 August 2018
Published: 21 December 2018
HIV-1, APOBEC3G mRNA, rs8177832, rs35228531, rs6001417, Burkina Faso.
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Authors

  • Tegwinde Rebeca Compaore
    rebecca23fr@yahoo.fr
    Pietro Annigoni Biomolecular Research Centre (CERBA)/LABIOGENE, University of Ouagadougou, Burkina Faso.
  • Serge Theophile Soubeiga Pietro Annigoni Biomolecular Research Centre (CERBA)/LABIOGENE, University of Ouagadougou,, Burkina Faso.
  • Abdoul Karim Ouattara Pietro Annigoni Biomolecular Research Centre (CERBA)/LABIOGENE, University of Ouagadougou, Burkina Faso.
  • Damehan Tchelougou Pietro Annigoni Biomolecular Research Centre (CERBA)/LABIOGENE, University of Ouagadougou, Burkina Faso.
  • Cyrille Bisseye Pietro Annigoni Biomolecular Research Centre (CERBA)/LABIOGENE, University of Ouagadougou, Burkina Faso.
  • Didier Romuald Bakouan Permanent Secretary Against Aids and Sexually Transmitted Diseases, Ouagadougou, Burkina Faso.
  • Issaka Compaore Pietro Annigoni Biomolecular Research Centre (CERBA)/LABIOGENE, University of Ouagadougou, Burkina Faso.
  • Augustine Dembele Permanent Secretary Against Aids and Sexually Transmitted Diseases, Ouagadougou, Burkina Faso.
  • Albert Theophane Yonli Pietro Annigoni Biomolecular Research Centre (CERBA)/LABIOGENE, University of Ouagadougou,, Burkina Faso.
  • Dorcas Obiri-Yeboah Microbiology Department, School of Medical Sciences, University of Cape Coast, Ghana.
  • Wendkuuni Florencia Djigma Pietro Annigoni Biomolecular Research Centre (CERBA)/LABIOGENE, University of Ouagadougou, Burkina Faso.
  • Jacques Simpore Pietro Annigoni Biomolecular Research Centre (CERBA)/LABIOGENE, University of Ouagadougou, Burkina Faso.

APOBEC3G is a potent inhibitor of HIV-1 replication, and act by deaminating cytidines in uracil on the negative strand of the viral cDNA. In this case-control study, APOBEC3G expression in subjects’ naïve to HAART infected by HIV-1 and the effect of APOBEC3G polymorphism on its expression were evaluated. The results show that the HIV-1 infected carriers of the G minor alleles of the variant rs8177832 had a higher expression of APOBEC3G mRNA than the controls carriers of the G minor allele. APOBEC3G polymorphisms could play an important role in the modulation of the HIV-1 dissemination.


Supporting Agencies

The Permanent Secretary for the fight against AIDS and STIs (CNLS/IST) of Burkina Faso; the WAEMU/PACER2 and the Pietro Annigoni Association.

Compaore, T. R., Soubeiga, S. T., Ouattara, A. K., Tchelougou, D., Bisseye, C., Bakouan, D. R., Compaore, I., Dembele, A., Yonli, A. T., Obiri-Yeboah, D., Djigma, W. F., & Simpore, J. (2018). APOBEC3G expression and HIV-1 infection in Burkina Faso. Journal of Public Health in Africa, 9(3). https://doi.org/10.4081/jphia.2018.907

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