Original Article

Effects of Eleutherine bulbosa (mill.) urb. bulb extract on mice glucocorticoid-induced osteoporosis models

Fina Luthfiana, Riza A. Sari, Irawati Sholikhah, Katsuyoshi Matsunami, Sukardiman Sukardiman, Retno Widyowati
Journal of Public Health in Africa | Vol 14, S 1 : 4th Joint Conference of UNAIR-USM, International Conference of Pharmacy and Health Sciences ICPHS| a108 | DOI: https://doi.org/10.4081/jphia.2023.2507 | © 2024 Fina Luthfiana, Riza A. Sari, Irawati Sholikhah, Katsuyoshi Matsunami, Sukardiman Sukardiman, Retno Widyowati | This work is licensed under CC Attribution 4.0
Submitted: 03 April 2024 | Published: 30 March 2023

About the author(s)

Fina Luthfiana, Master Program of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Indonesia
Riza A. Sari, Master Program of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Indonesia
Irawati Sholikhah, Department of Chemistry, Faculty of Sains and Technology, Universitas Airlangga, Indonesia
Katsuyoshi Matsunami, Department of Pharmacognosy, Graduate School of Biomedical & Health Sciences, Hiroshima University, Japan
Sukardiman Sukardiman, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Indonesia; and, Natural Products Drug Discovery and Development, Faculty of Pharmacy, Universitas Airlangga, Indonesia
Retno Widyowati, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Indonesia; and, Natural Products Drug Discovery and Development, Faculty of Pharmacy, Universitas Airlangga, Indonesia

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Abstract

ackground: Low bone mass accompanied by microarchitectural alterations in the bone that cause fragility fractures is known as secondary osteoporosis and occurs when there is an underlying condition or medication present. Eleutherine bulbosa bulb extract has been shown to affect bone because of its content, which can help osteoblast differentiation and inhibit osteoclast differentiation. Objective: This study aimed to assess the effects of 70% ethanol extract of E. bulbosa Bulbs (EBE) from Pasuruan-East Java on blood calcium levels, osteoblast cell count, and bone density of trabecular femur in osteoporosis rats. Methods: Six groups of 30 female Wistar rats were created. There were no test materials offered to the healthy group; the negative group received 0.5% CMC; the positive group received alendronate 0.9 mg/kg BW; and the dose group received 30, 60, and 120 mg/kg BW. Glucocorticoid (Dexamethasone) 0.1015 mg/kg BW/day induction was given to all groups except the healthy group to create osteoporosis rats for approximately four weeks. Then they were given oral therapy for approximately 28 days. Followed by the determination of blood calcium levels, the number of osteoblast cells, and bone density of the rat femur trabecular. Results: The result showed that E. bulbosa bulbs extract could raise blood calcium levels and bone density percentage at doses of 60 and 120 mg/kg BW, as well as raise osteoblast cell levels at doses of 120 mg/kg BW. Conclusions: The findings indicate that E.bulbosa bulb extract is a potential complementary medicine for osteoporosis.

Keywords

Eleutherine bulbosa; Calcium; Osteoblast cell; Bone density; Osteoporosis

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