Original Article

The activity of candlenut oil in the nanostructured lipid carrier system on hair growth in rats

Tristiana M. Erawati, Noorma Rosita, Intan Rachmania
Journal of Public Health in Africa | Vol 14, S 1 : 4th Joint Conference of UNAIR-USM, International Conference of Pharmacy and Health Sciences ICPHS| a130 | DOI: https://doi.org/10.4081/jphia.2023.2519 | © 2024 Tristiana M. Erawati, Noorma Rosita, Intan Rachmania | This work is licensed under CC Attribution 4.0
Submitted: 03 April 2024 | Published: 30 March 2023

About the author(s)

Tristiana M. Erawati, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
Noorma Rosita, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
Intan Rachmania, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia

Full Text:

PDF (646KB)

Abstract

Background: Candlenut oil (Aleurites moluccana L. Willd), which is also called Aleurites moluccana Seed (AMS) oil, is empirically effective as a hair growth agent, it is an unstable substance. Nanostructured Lipid Carrier (NLC) is a delivery system that is proven to increase the effectiveness and stability of the material, and the usage of solid lipid combination: beeswax-oleum cacao can produce good NLC characteristics. Objective: To determine the effectiveness of NLC_AMS oil with different combination of beeswax-oleum cacao (100:0; 50:50; 25:75; and 0:100) as a hair growth agent, using rats as subjects. Methods: NLC-AMS oil was made using 20% of total lipid with 5% AMS oil as liquid lipid and 15% solid lipid; combinations of beeswax-oleum cacao were of different ratios (100:0; 50:50; 25:75; and 0:100). NLC was made by High Shear Homogenization (HPH) method. Hair growth activity test carried out on male white rats using the research methods of Yoon (2010). Results: The addition of oleum cacao as a solid lipid did not affect the pH, but increased the consistency and decreased the particle size of NLC- AMS oil. There was a relationship between the characteristic of NLC and the hair growth activity test: the small particle size and low viscosity had greater hair growth activity. Conclusion: The usage of solid lipid combination: beeswax-oleum cacao can produce better NLC characteristics and had higher hair growth activity than the formulas that used single lipid.

Keywords

Candlenut oil; AMS oil; nanostructured lipid carrier (NLC); hair growth

Metrics

Total abstract views: 176
Total article views: 28


Crossref Citations

No related citations found.