Original Article

Microscopic and physicochemical evaluation of Ruta angustifolia leaves

Tutik S. Wahyuni, Ni’matul Khoiriyah, Lidya Tumewu, Wiwied Ekasari, Achmad Fuad, Aty Widyawaruyanti
Journal of Public Health in Africa | Vol 14, S 1 : 4th Joint Conference of UNAIR-USM, International Conference of Pharmacy and Health Sciences ICPHS| a131 | DOI: https://doi.org/10.4081/jphia.2023.2520 | © 2024 Tutik S. Wahyuni, Ni’matul Khoiriyah, Lidya Tumewu, Wiwied Ekasari, Achmad Fuad, Aty Widyawaruyanti | This work is licensed under CC Attribution 4.0
Submitted: 03 April 2024 | Published: 30 March 2023

About the author(s)

Tutik S. Wahyuni, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya; and, Indonesia; Center of Natural Product Medicine Research and Development, Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia
Ni’matul Khoiriyah, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
Lidya Tumewu, Center of Natural Product Medicine Research and Development, Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia
Wiwied Ekasari, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya; and, Indonesia; Center of Natural Product Medicine Research and Development, Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia
Achmad Fuad, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya; and, Indonesia; Center of Natural Product Medicine Research and Development, Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia
Aty Widyawaruyanti, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya; and, Indonesia; Center of Natural Product Medicine Research and Development, Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia

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Abstract

ackground: There are thousands of species of known medicinal plants in the world. Ruta angustifolia L. has been widely used in traditional medication for jaundice and liver disease. Previous studies have shown that R. angustifolia leaves can inhibit the hepatitis C virus in Huhit culture cells, reduce the value of NS3 protein, and possess a synergistic effect in combination with antiviral drugs. Therefore, this plant is potential to be developed as a drug candidate. Characteristics of plants including microscopic, physicochemical properties, and phytochemical profiles are necessary information to ensure the quality of raw material in drug development. Objective: This study was carried out to examine the microscopic and physicochemical including the standardized parameter of R. angustifolia leaves to fulfil the quality raw materials as traditional medicine. Methods: Simplicia of R. angustifolia leaves obtained from Jombang, East Java, were observed under a microscope and determined its physicochemical properties referred to the Materia Medica Indonesia V. The TLC and HPLC profiles of extract were determined as well. Results: Microscopic analysis were conducted by transfection sections and the presence of epidermis cells, palisade, mesophyll with stomata, and Ca-oxalate crystal were found. The standard parameter obtained value of loss of drying, extractive value in water and ethanol, and ash value. The TLC and HPLC profiles of leaves extract demonstrated to contain with flavonoid, terpenoids, and alkaloids. Conclusion: Ruta angustifolia obtained from Jombang, east Java, has a specific character in microscopic analysis. The physicochemical properties analysis of R. angustifolia leaves as a raw material met the requirements according to Materia Medica Indonesia V.

Keywords

Ruta angustifolia; ethnographic account; medicinal plants; Northern Tigray; Asgede Tsimbla; raw material; infectious disease

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