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This study examined the demographic implications of the HIV prevalence trend in Nigeria. Data from the 2010 National Antenatal Sentinel Survey was used to produce various graphs to determine the trend of HIV at the national level, state levels, urban and rural areas, and various age groups. This study has found that though a decline exists in the national HIV prevalence and the HIV prevalence among women aged 15-24 years, there is a potential for an increased trend if adequate HIV services are not provided in rural areas. This is because the HIV prevalence in many states has risen between 2008 and 2010 owing to a rise in HIV prevalence in rural areas and in women aged 15-39 years. This study has significant implications for achieving Millennium Development Goals 4, 5, and 6 related to HIV in Nigeria and other Sub-Saharan countries.
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