Prevalence of hepatitis C among HIV-1, HIV-2 and dually reactive patients: A multi-country cross-sectional survey in West Africa

  • Didier K. Ekouevi | didier.ekouevi@gmail.com Université de Lomé, Département de Santé Publique, Lomé-Togo, ISPED, Université de Bordeaux and Centre INSERM U1219 - Bordeaux Population Health, Bordeaux, France; Programme PACCI, site de recherche ANRS, Abidjan, Côte d'Ivoire.
  • Patrick A. Coffie ISPED, Université de Bordeaux and Centre INSERM U1219 - Bordeaux Population Health, Bordeaux, France; Programme PACCI, site de recherche ANRS, Abidjan, Côte d’Ivoire; Département de Dermatologie et d’Infectiologie, UFR des Sciences Médicales, Université Félix Houphouët Boigny, Abidjan, Côte d'Ivoire.
  • Boris K. Tchounga ISPED, Université de Bordeaux and Centre INSERM U1219 - Bordeaux Population Health, Bordeaux, France; Programme PACCI, site de recherche ANRS, Abidjan, Côte d’Ivoire; Département de Dermatologie et d’Infectiologie, UFR des Sciences Médicales, Université Félix Houphouët Boigny, Abidjan, Côte d'Ivoire.
  • Armel Poda Université Polytechnique de Bobo, Institut Supérieur des Sciences de la Santé, Bobo-Dioulasso, Burkina Faso; Hôpital de Jour de Bobo, Service des Maladies Infectieuses (CHU Souro Sanou), Bobo-Dioulasso, Burkina Faso.
  • Antoine Jaquet ISPED, Université de Bordeaux and Centre INSERM U1219 - Bordeaux Population Health, Bordeaux, France.
  • François Dabis ISPED, Université de Bordeaux and Centre INSERM U1219 - Bordeaux Population Health, Bordeaux, France; Programme PACCI, site de recherche ANRS, Abidjan, Côte d’Ivoire; Département de Dermatologie et d’Infectiologie, UFR des Sciences Médicales, Université Félix Houphouët Boigny, Abidjan, Côte d'Ivoire.
  • Serge P. Eholie Programme PACCI, site de recherche ANRS, Abidjan; Département de Dermatologie et d’Infectiologie, UFR des Sciences Médicales, Université Félix Houphouët Boigny, Abidjan; Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Treichville, Abidjan, Côte d'Ivoire.

Abstract

Little is known on the impact of HIV-2 infection on HCV viral replication. The aim of the study was to compare HCV prevalence and viral replication based on HIV types in West Africa. A cross-sectional survey was conducted within the IeDEA HIV-2 West Africa cohort from March to December 2012. All HIVinfected adult patients who attended participating HIV clinics during the study period were included. Blood samples were collected and re-tested for HIV type discrimination, HCV serology and viral load. A total of 767 patients were enrolled: 186 HIV-1, 431 HIV-2 and 150 HIV-1&2 dually reactive. At time of sampling, 531 (69.2%) were on ART and median CD4+ cell count was 472/mm3. Thirty (3.9%, 95% CI 2.7-5.5) patients were anti-HCV positive (4.3% in HIV-1, 4.0% in HIV-1&2 dually reactive and 3.7% in HIV-2; p=0.91). Detectable HCV RNA was identified in 21 (70.0%) patients (100% in HIV-1 and HIV- 1&2 dually reactive vs. 43.8% in HIV-2; p=0.003). Systematic screening should be promoted and performed in this population, since HCV is now potentially curable in sub- Saharan Africa.

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Published
2018-10-10
Section
Original Articles
Keywords:
HIV-2, HCV, HBV, West Africa
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How to Cite
Ekouevi, D., Coffie, P., Tchounga, B., Poda, A., Jaquet, A., Dabis, F., & Eholie, S. (2018). Prevalence of hepatitis C among HIV-1, HIV-2 and dually reactive patients: A multi-country cross-sectional survey in West Africa. Journal of Public Health in Africa, 9(2). https://doi.org/10.4081/jphia.2018.871