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Sociodemographic, lifestyle and therapeutic predictors of 2-year survival in HIV-infected persons receiving antiretroviral therapy in Benin

Charles Sossa Jerome, Maurice Agonnoudé, Ghislain Emmanuel Sopoh, Ali Imorou Bah-Chabi, Amédée de Souza, Moussa Bachabi, Gratien Gbetowenonmon, Victoire Agueh, Edgard-Marius Ouendo, Laurent Ouédraogo
  • Maurice Agonnoudé
    National School of Epidemiology and Public Health, University of Parakou, Benin
  • Ghislain Emmanuel Sopoh
    Regional Institute of Public Health, University of Abomey-Calavi, Benin
  • Ali Imorou Bah-Chabi
    National Program for Fight against AIDS (PNLS), Benin
  • Amédée de Souza
    National Program for Fight against AIDS (PNLS), Benin
  • Moussa Bachabi
    National Program for Fight against AIDS (PNLS), Benin
  • Gratien Gbetowenonmon
    National Program for Fight against AIDS (PNLS), Benin
  • Victoire Agueh
    Regional Institute of Public Health, University of Abomey-Calavi, Benin
  • Edgard-Marius Ouendo
    Regional Institute of Public Health, University of Abomey-Calavi, Benin
  • Laurent Ouédraogo
    Regional Institute of Public Health, University of Abomey-Calavi, Benin

Abstract

The benefits of antiretroviral therapy (ART) for treating human immunodeficiency virus (HIV) infection have been well described. The objective of this study was to identify the predictors of two-year survival in persons living with HIV/AIDS (PLWHA) in Benin. This retrospective transversal study included all patients from 46 HIV/AIDS therapy sites across Benin who started ART between July 1st, 2011 and June 30th, 2012. The independent variables were patients’ sociodemographic, clinical, biological and therapeutic characteristics and their ART regimen. The main dependent variable was the time of death. Data were collected from medical records, using documentary review. Cox proportional hazards regression models were used to investigate factors associated with survival. Among the 771 PLWHA participants of the study, 18 (2.3%) died within the two-year period. The estimated mortality of the 771 PLWHA was 3% at 24 months. Among the sociodemographic, lifestyle and therapeutic characteristics studied, the main predictor of two-year mortality was poor adherence [odds ratio = 4.15, 95% confidence interval (1.55- 11.28)]. This study confirms that improving the survival of PLWHA receiving ART requires enhanced adherence.

Keywords

HIV/AIDS, survival, antiretroviral therapy, predictors, Benin

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Submitted: 2017-01-13 09:33:02
Published: 2017-09-27 08:25:02
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Copyright (c) 2017 Charles Sossa Jerome, Maurice Agonnoudé, Ghislain Emmanuel Sopoh, Ali Imorou Bah-Chabi, Amédée de Souza, Moussa Bachabi, Gratien Gbetowenonmon, Victoire Agueh, Edgard-Marius Ouendo, Laurent Ouédraogo

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