A brief review on features of falciparum malaria during pregnancy

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Alexandre Manirakiza (1*), Eugène Serdouma (2), Richard Norbert Ngbalé (3), Sandrine Moussa (4), Samuel Gondjé (5), Rock Mbetid Degana (6), Gislain Géraud Banthas Bata (7), Jean Methode Moyen (8), Jean Delmont (9), Gérard Grésenguet (10), Abdoulaye Sepou (11)

1 Pasteur Institute of Bangui, Bangui, Central African Republic.
2 University of Bangui, Bangui, Central African Republic.
3 University of Bangui, Bangui, Central African Republic.
4 Pasteur Institute of Bangui, Bangui, Central African Republic.
5 Ministry of Public Health, Population and AIDS Control, Bangui, Central African Republic.
6 Ministry of Public Health, Population and AIDS Control, Bangui, Central African Republic.
7 Ministry of Public Health, Population and AIDS Control, Bangui, Central African Republic.
8 Ministry of Public Health, Population and AIDS Control, Bangui, Central African Republic.
9 Center for Training and Research in Tropical Medicine and Health, Faculty of Medicine North, Marseille, France.
10 University of Bangui, Bangui, Central African Republic.
11 University of Bangui, Bangui, Central African Republic.
(*) Corresponding Author:
Alexandre Manirakiza
alexandre.manirakiza@pasteur-bangui.org
http://orcid.org/0000-0002-1873-8527

Abstract

Malaria in pregnancy is a serious public health problem in tropical areas. Frequently, the placenta is infected by accumulation of Plasmodium falciparum-infected erythrocytes in the intervillous space. Falciparum malaria acts during pregnancy by a range of mechanisms, and chronic or repeated infection and co-infections have insidious effects. The susceptibility of pregnant women to malaria is due to both immunological and humoral changes. Until a malaria vaccine becomes available, the deleterious effects of malaria in pregnancy can be avoided by protection against infection and prompt treatment with safe, effective antimalarial agents; however, concurrent infections such as with HIV and helminths during pregnancy are jeopardizing malaria control in sub-Saharan Africa.

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How to Cite
Manirakiza, A., Serdouma, E., Ngbalé, R. N., Moussa, S., Gondjé, S., Mbetid Degana, R., Banthas Bata, G. G., Moyen, J. M., Delmont, J., Grésenguet, G., & Sepou, A. (2017). A brief review on features of falciparum malaria during pregnancy. Journal of Public Health in Africa, 8(2). https://doi.org/10.4081/jphia.2017.668