Factors associated with multi-drug-resistant tuberculosis in Dakar, Senegal, 2010-2016

  • Mbouna Ndiaye West Africa Field Epidemiology Training Program (WAFETP), Burkina Faso.
  • Pauline Kiswendsida Yanogo | y_poline@yahoo.fr West Africa Field Epidemiology Training Program (WAFETP), and Faculty of Medicine, University Ouaga 1, Professor Joseph Ki-zerbo, Burkina Faso.
  • Bernard Sawadogo West Africa Field Epidemiology Training Programme (WAFETP), Burkina Faso.
  • Fadima Diallo West Africa Field Epidemiology Training Programme (WAFETP), Burkina Faso.
  • Simon Antara West Africa Field Epidemiology Training Programme (WAFETP), Burkina Faso.
  • Nicolas Meda West Africa Field Epidemiology Training Program (WAFETP), and 2aculty of Medicine, University Ouaga 1, Professor Joseph Ki-zerbo, Burkina Faso.

Abstract

According to the World Health Organization, multidrug-resistant tuberculosis (MDR-TB) represents a major obstacle towards successful TB treatment and control. In Dakar, MDR-TB management began in 2010 with the strengthening of diagnostic resources. The objective of this study was to identify the factors associated with multidrug-resistant tuberculosis in Dakar between 2010 and 2016. We conducted a case-control study from January 10 to February 28, 2017 in tuberculosis centers in Dakar. of 169 cases and 507 controls. We used logistic regression with Epi-info version 7.2.1. to estimate the odds ratios of association. Factors significantly associated with MDR-TB were: residing in a periurban area (ORa=1.8; 95% CI (1.5-4.9); p=0.024), presence of MDR-TB in the entourage of patient (ORa=7.0; 95% CI (6.1-9.5); p=0.002), previous treatment failure (ORa=29.5; 95% CI (27.3-30.1); p=0.000), treatment not directly observed by a health care provider (ORa=4.3; 95% CI (4.1-7,2); p=0.000) and irregularity of treatment (ORa=1.7; 95% CI (0.5-5.4); p=0.037). Focusing interventions on population at-risk will prevent MDR-TB.

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Published
2020-03-20
Section
Original Articles
Keywords:
multidrug-resistant tuberculosis, factors, Dakar
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How to Cite
Ndiaye, M., Yanogo, P., Sawadogo, B., Diallo, F., Antara, S., & Meda, N. (2020). Factors associated with multi-drug-resistant tuberculosis in Dakar, Senegal, 2010-2016. Journal of Public Health in Africa, 10(2). https://doi.org/10.4081/jphia.2019.1099