No correlation between the variants of exostosin 2 gene and type 2 diabetes in Burkina Faso population

  • Serge Yannick Ouedraogo Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou, Burkina Faso. https://orcid.org/0000-0002-4998-8596
  • Daméhan Tchelougou Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou, Burkina Faso.
  • Jonas Koudougou Kologo Saint Camille Hospital (HOSCO), Ouagadougou, Burkina Faso.
  • Herman Karim Sombie Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou, Burkina Faso. https://orcid.org/0000-0001-6996-8990
  • Moutanou Modeste Judes Zeye Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou, Burkina Faso. https://orcid.org/0000-0002-3407-9576
  • Rebeca Tégwindé Compaore Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou; Biomolecular Research Center Pietro Annigoni (CERBA), Ouagadougou, Burkina Faso.
  • Abdoul Karim Ouattara Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou, Burkina Faso. https://orcid.org/0000-0002-9767-0646
  • Abel Pegdwendé Sorgho Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou, Burkina Faso.
  • Dorcas Obiri-Yeboah Obiri-Yeboah Department of Microbiology and Immunology, School of Medical Sciences, University of Cape Coast, Ghana. https://orcid.org/0000-0003-4562-9294
  • Serge Théophile Soubeiga Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou, Burkina Faso. https://orcid.org/0000-0002-9741-2428
  • Issoufou Nagabila Saint Camille Hospital (HOSCO), Ouagadougou, Burkina Faso.
  • Albert Théophane Yonli Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou; Biomolecular Research Center Pietro Annigoni (CERBA), Ouagadougou, Burkina Faso.
  • Florencia Wendkuuni Djigma | florencia.djigma@gmail.com Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou; Biomolecular Research Center Pietro Annigoni (CERBA), Ouagadougou;, Burkina Faso. https://orcid.org/0000-0002-6895-6725
  • Jacques Simpore Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou; Saint Camille Hospital (HOSCO), Ouagadougou; Biomolecular Research Center Pietro Annigoni (CERBA), Ouagadougou, Burkina Faso. https://orcid.org/0000-0002-0415-9161

Abstract

Recent genome-wide association studies and replication analyses have reported the association of variants of the exostosin- 2 gene (EXT2) and risk of type 2 diabetes (T2D) in some populations, but not in others. This study aimed to characterize the variants rs1113132, rs3740878 and rs11037909 of EXT2 and to determine the existence of a possible correlation with T2D in Burkina Faso. It is a case-control study undertaken in Burkina Faso in the city of Ouagadougou at the Hospital of Saint Camille of Ouagadougou from December 2014 to June 2015. It relates to 121 type 2 diabetes cases and 134 controls. The genotyping of these polymorphisms was done by real-time PCR using the allelic exclusion method with TaqMan probes. The minor allele frequencies (MAFs) was almost identical in diabetic and control subjects for the all three Single Nucleotide Polymorphisms (SNPs) with no statistical significance, p>0.05: rs1113132 (OR=0.89; p=0.82); rs11037909 (OR=0.89; p=0.74) and rs3740878 (OR=1.52; p=0.42). None of the three polymorphisms studied was associated with the risk of DT2. However, an association between the BMI, age and type 2 diabetes was noted. The variants of EXT2 would not be associated to the risk of T2D in the African black population of Burkina Faso.

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Published
2020-10-29
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Original Articles
Keywords:
Type 2 Diabetes, Exostosin-2, association, SNPs, Burkina Faso
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How to Cite
Ouedraogo, S. Y., Tchelougou, D., Kologo, J. K., Sombie, H. K., Zeye, M. M. J., Compaore, R. T., Ouattara, A. K., Sorgho, A. P., Obiri-Yeboah, D. O.-Y., Soubeiga, S. T., Nagabila, I., Yonli, A. T., Djigma, F. W., & Simpore, J. (2020). No correlation between the variants of exostosin 2 gene and type 2 diabetes in Burkina Faso population. Journal of Public Health in Africa, 11(1). https://doi.org/10.4081/jphia.2020.1233