Email this article 
Hide
Show all
Original Research
Latent tuberculosis infection in family members in household contact with active tuberculosis patients in Semarang City, Central Java, Indonesia
Submitted: 11 April 2024 | Published: 26 July 2022
About the author(s)
Karbito Karbito, Faculty of Public Health, Diponegoro University, Semarang, Central Java, IndonesiaHardhono Susanto, Faculty of Medicine, Diponegoro University, Semarang, Central Java, Indonesia
Mateus S. Adi, Faculty of Public Health, Diponegoro University, Semarang, Central Java, Indonesia
Sulistiyani Sulistiyani, Faculty of Public Health, Diponegoro University, Semarang, Central Java, Indonesia
Oktia W.K. Handayani, Faculty of Public Health, Semarang State University, Semarang, Central Java, Indonesia
Muchlis A.U. Sofro, Faculty of Medicine, Diponegoro University, Semarang, Central Java, Indonesia
Full Text:
PDF (5MB)Abstract
A quarter of the world’s population is infected with Mycobacterium tuberculosis (M.tb), 10% of cases develop active tuberculosis (TB), and 90% have a latent TB infection. Family members of TB patients have the highest potential for latent TB infection. This study aims to identify latent TB infection and risk factors in family members within the household contacts of active TB patients. This study used a crosssectional study design with a contact tracing method. The selected subjects were 138 people from 241 total family members of 112 active TB patients. Subjects underwent a tuberculin skin test (TST), using 2 units of tuberculin (TU) purified protein derivative (PPD) 0.1 mL (PT. Bio Farma Persero, Bandung, Indonesia). Data risk factors were collected during home visits. Data were analyzed using the chi-square test and multiple logistic regression. A total of 63.8% (88/138) of family members of active TB patients’ household contacts had latent TB infection. The type of occupation of laborers/ farmers/fishers is the most dominant risk factor associated with latent TB infection (AOR: 7.04; 95% CI: 1.70–29.02), followed by unqualified bedroom density (<8 m2/2 people) (AOR: 5.33; 95% CI: 2.44– 12.71) and contact duration ≥5 hours/day (AOR: 4.70; 95% CI:1.33–16.66). Latent TB infection in family members of active TB patients’ household contacts was quite high. Occupation type, contact duration, and bedroom density were simultaneously confirmed as the main risk factors related to latent TB infection. Therefore, it is recommended to identify and prevent latent TB infection in family members in household contact with active TB patients.
Keywords
Metrics
Total abstract views: 3100Total article views: 819
Crossref Citations
1. Burden of pulmonary tuberculosis among Ethiopians seeking jobs in the Middle East: a retrospective study
Haimanot Disassa, Yoseph Addisu, Ashebir Gebre, Zekaria Abdulhamid, Berhanu Seyoum, Gobena Ameni, Balako Gumi, M. Sanni Ali
BMC Public Health vol: 25 issue: 1 year: 2025
doi: 10.1186/s12889-025-24715-8
2. Tuberculosis Case Finding Using Self-Assessment Paradigm Through the E-TIBI Application in HIV Patients
Erwin Astha Triyono, Merita Arini, Feriawan Tan, Lilis Masyfufah
F1000Research vol: 13 first page: 750 year: 2025
doi: 10.12688/f1000research.152632.2
3. Tuberculosis Infection in Children and Adolescents
Boris Tchakounte Youngui, Boris Kevin Tchounga, Stephen M. Graham, Maryline Bonnet
Pathogens vol: 11 issue: 12 first page: 1512 year: 2022
doi: 10.3390/pathogens11121512
4. Prevalence of tuberculosis infection among contacts of drug-resistant tuberculosis patients: A systematic review and meta-analysis
Temesgen Yihunie Akalu, Archie C.A. Clements, Eyob Alemayehu Gebreyohannes, Beth Gilmour, Kefyalew Addis Alene
Journal of Infection vol: 89 issue: 2 first page: 106198 year: 2024
doi: 10.1016/j.jinf.2024.106198
5. TBL-20Q-IDN: Validation of Tuberculosis Literacy Instrument in Urban Settings
Kismi Mubarokah, Nurjanah Nurjanah, M.G. Catur Yuantari, Supriyono Asfawi, Ratih Pramitasari, Vilda AnaVeria Setyawati, Enny Rachmani, Slamet Isworo, Anamarija Jurćev Savićević, Marijana Geets-Kesić, M.I. Kartasurya, J.-H. Han, K.-H. Tsai, S. Nursheena, S. Changrob, N. Lisnawati, A.F. Asna, N. Handayani, D.Z. Nuridzin
BIO Web of Conferences vol: 133 first page: 00017 year: 2024
doi: 10.1051/bioconf/202413300017
6. Determining the Need for Additional Testing With Quantiferon TB Gold in Patients With Positive Tuberculin Skin Tests and a History of BCG Vaccination
Antony J Arumairaj, Hansang Park, Fernando Quesada, Brian Altonen, Shobhana Chaudhari, Joseph Mattana, Imnett Habtes
Cureus year: 2023
doi: 10.7759/cureus.39272
7. Tuberculosis Case Finding Using Self-Assessment Paradigm Through the E-TIBI Application in HIV Patients
Erwin Astha Triyono, Merita Arini, Feriawan Tan, Lilis Masyfufah
F1000Research vol: 13 first page: 750 year: 2024
doi: 10.12688/f1000research.152632.1
8. Evaluating Treatment Outcomes and Tuberculosis Infection Risks: A Comparative Study of Centralized Hospitalization vs. Home-Based Treatment
Fangming Xianyu, Yuemei Huang, Shengqiong Guo, Virasakdi Chongsuvivatwong
Tropical Medicine and Infectious Disease vol: 9 issue: 5 first page: 119 year: 2024
doi: 10.3390/tropicalmed9050119
9. Latent Tuberculosis Infection among Household Contacts of Tuberculosis Patients, Healthcare Workers, and Tuberculosis Patients Using QuantiFERON-tuberculosis Gold Plus and Tuberculin Skin Test in a Tertiary Care Hospital Setting Bhubaneswar, Odisha – A Cross-sectional Study
Braja Sundar Barik, Chinmay Divyadarshi Kar, Shritam Das, Tahziba Hussain, Sasmita Nayak, Arun Kumar Sahu, Sooman Sundaray, Sanghamitra Pati
Journal of Global Infectious Diseases vol: 17 issue: 1 first page: 52 year: 2025
doi: 10.4103/jgid.jgid_78_24
10. Tingkat Pengetahuan Keluarga Tinggal Serumah Tentang Pencegahan Penularan Pasien Tuberkulosis Paru
Komang Yuliani, I Dewa Agung Ketut Sudarsana
Journal Nursing Research Publication Media (NURSEPEDIA) vol: 2 issue: 1 first page: 47 year: 2023
doi: 10.55887/nrpm.v2i1.34
11. The Yield of Active Tuberculosis Disease and Latent Tuberculosis Infection in Tuberculosis Household Contacts Investigated Using Chest X-ray in Yogyakarta Province, Indonesia
Betty Nababan, Rina Triasih, Geoffrey Chan, Bintari Dwihardiani, Arif Hidayat, Setyogati C. Dewi, Lana Unwanah, Arif Mustofa, Philipp du Cros
Tropical Medicine and Infectious Disease vol: 9 issue: 2 first page: 34 year: 2024
doi: 10.3390/tropicalmed9020034
12. Age differences in factors associated with pulmonary tuberculosis: a cross-sectional study of Indonesian Basic Health Research (RISKESDAS) 2018
Erni W. Susanti, Bayu S. Wiratama, Fang-I Hsieh
Infectious Diseases first page: 1 year: 2025
doi: 10.1080/23744235.2025.2562230