Original Research
No correlation between the variants of exostosin 2 gene and type 2 diabetes in Burkina Faso population
Journal of Public Health in Africa | Vol 11, No 1 | a550 |
DOI: https://doi.org/10.4081/jphia.2020.1233
| © 2024 Serge Y. Ouedraogo, Daméhan Tchelougou, Jonas K. Kologo, Herman K. Sombie, Moutanou M.J. Zeye, Rebeca T. Compaore, Abdoul K. Ouattara, Abel P. Sorgho, Dorcas Obiri-Yeboah, Serge T. Soubeiga, Issoufou Nagabila, Albert T. Yonli, Florencia W. Djigma, Jacques Simpore
| This work is licensed under CC Attribution 4.0
Submitted: 24 April 2024 | Published: 29 April 2020
Submitted: 24 April 2024 | Published: 29 April 2020
About the author(s)
Serge Y. Ouedraogo, Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou, Burkina FasoDaméhan Tchelougou, Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou, Burkina Faso
Jonas K. Kologo, Saint Camille Hospital (HOSCO), Ouagadougou, Burkina Faso
Herman K. Sombie, Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou, Burkina Faso
Moutanou M.J. Zeye, Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou, Burkina Faso
Rebeca T. Compaore, Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou; and, Biomolecular Research Center Pietro Annigoni (CERBA), Ouagadougou, Burkina Faso
Abdoul K. Ouattara, Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou, Burkina Faso
Abel P. Sorgho, Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou, Burkina Faso
Dorcas Obiri-Yeboah, Department of Microbiology and Immunology, School of Medical Sciences, University of Cape Coast, Ghana
Serge T. Soubeiga, Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou, Burkina Faso
Issoufou Nagabila, Saint Camille Hospital (HOSCO), Ouagadougou, Burkina Faso
Albert T. Yonli, Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou; and, Biomolecular Research Center Pietro Annigoni (CERBA), Ouagadougou, Burkina Faso
Florencia W. Djigma, Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou; and, Biomolecular Research Center Pietro Annigoni (CERBA), Ouagadougou, Burkina Faso
Jacques Simpore, Laboratory of Molecular Biology and Genetic (LABIOGENE), Ouagadougou; Saint Camille Hospital (HOSCO), Ouagadougou; Biomolecular Research Center Pietro Annigoni (CERBA), Ouagadougou, Burkina Faso
Full Text:
PDF (356KB)Abstract
Recent genome-wide association studies and replication analyses have reported the association of variants of the exostosin- 2 gene (EXT2) and risk of type 2 diabetes (T2D) in some populations, but not in others. This study aimed to characterize the variants rs1113132, rs3740878 and rs11037909 of EXT2 and to determine the existence of a possible correlation with T2D in Burkina Faso. It is a case-control study undertaken in Burkina Faso in the city of Ouagadougou at the Hospital of Saint Camille of Ouagadougou from December 2014 to June 2015. It relates to 121 type 2 diabetes cases and 134 controls. The genotyping of these polymorphisms was done by real-time PCR using the allelic exclusion method with TaqMan probes. The minor allele frequencies (MAFs) was almost identical in diabetic and control subjects for the all three Single Nucleotide Polymorphisms (SNPs) with no statistical significance, p>0.05: rs1113132 (OR=0.89; p=0.82); rs11037909 (OR=0.89; p=0.74) and rs3740878 (OR=1.52; p=0.42). None of the three polymorphisms studied was associated with the risk of DT2. However, an association between the BMI, age and type 2 diabetes was noted. The variants of EXT2 would not be associated to the risk of T2D in the African black population of Burkina Faso.
Keywords
Type 2 Diabetes; Exostosin-2; association; SNPs; Burkina Faso
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