Original Research

The dissolution of p-methoxycinnamic acid-β-cyclodextrin inclusion complex produced with microwave irradiation

Dewi Isadiartuti, Juni Ekowati, Noorma Rosita, Nabella R. Amalia
Journal of Public Health in Africa | Vol 14, S 1 : 4th Joint Conference of UNAIR-USM, International Conference of Pharmacy and Health Sciences ICPHS| a93 | DOI: https://doi.org/10.4081/jphia.2023.2500 | © 2024 Dewi Isadiartuti, Juni Ekowati, Noorma Rosita, Nabella R. Amalia | This work is licensed under CC Attribution 4.0
Submitted: 03 April 2024 | Published: 30 March 2023

About the author(s)

Dewi Isadiartuti, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
Juni Ekowati, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
Noorma Rosita, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
Nabella R. Amalia, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia

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Abstract

ackground: p-methoxycinnamic acid (pMCA) is an ethyl p-methoxycinnamic derivative, which is the largest active ingredient in the rhizome of the kencur (Kaempferia galanga L) plant. Several studies reported that the compound has anti-inflammatory activity but has low solubility in water. The formation of a pMCA-β-cyclodextrin (βCD) inclusion complex with a molar ratio of 1:1 can increase its solubility. The formation of inclusion complexes with conventional methods requires a long time and the yield value is not optimal. Objective: This study aims to evaluate the dissolution of the pMCA-βCD inclusion complex produced using the microwave irradiation method. Methods: The product was manufactured with chloroform solvent and a power of 400 watts (power 80%). It was then evaluated using the Differential Thermal Analysis (DTA) every 2 minutes until the 8th minute. The reaction was complete after 4 minutes of treatment with a yield of 96.5%. The obtained inclusion complexes were evaluated using DTA, FTIR, and PXRD. Subsequently, a dissolution test was carried out using a type 2 apparatus in distilled water medium of pH 6.8±0.05 at 37±0.5°C. Results: The results showed that there was a change in the melting temperature profile, infrared spectra, and crystallinity of the product. An 89.18% dissolution was also obtained within 60 minutes, which was twice that of pMCA compounds. Conclusion: From the results of the study, it can be concluded that the formation of pMCA-βCD inclusion complexes using the microwave irradiation method is capable of providing high-yield values in a short time.

Keywords

Dissolution, p-methoxycinnamic acid; β-cyclodextrin; Microwave irradiation; Drug

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